ID A0A176LAS5_9ACTN Unreviewed; 743 AA.
AC A0A176LAS5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=A6P39_06350 {ECO:0000313|EMBL:OAB01599.1};
OS Streptomyces sp. FXJ1.172.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=710705 {ECO:0000313|EMBL:OAB01599.1};
RN [1] {ECO:0000313|EMBL:OAB01599.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FXJ1.172 {ECO:0000313|EMBL:OAB01599.1};
RA Liu M., Liu N., Shang F., Huang Y.;
RT "Activation and identification of NC-1, a novel cryptic cyclodepsipeptide
RT from red soil-derived Streptomyces sp. FXJ1.172.";
RL Submitted (APR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAB01599.1}.
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DR EMBL; LWRP01000044; OAB01599.1; -; Genomic_DNA.
DR RefSeq; WP_067040610.1; NZ_CP119133.1.
DR AlphaFoldDB; A0A176LAS5; -.
DR STRING; 710705.A6P39_06350; -.
DR OrthoDB; 7051771at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..743
FT /note="SSD domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5038390671"
FT TRANSMEM 177..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 522..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 635..654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..326
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 743 AA; 77660 MW; 14C8E46AC6B2075A CRC64;
MADLARWCVR HRLIAVLLWL LAFGGTSAAA AVAGTSYSND YQVPGTESGR AEQLLKQGFP
GLGGDSDTVV WHTAGGTVRD TGVEQAMTRT LDRISALPGV ASVSGPYGRA GAHRISDDGR
TAYATVTFGR PSEEIGKSEA QAVVRTAKAA ERDGLQVELG GDAIALTASP REHTAELVGV
LVAAVVLFLA FGSLAASLLP IATALVGVGT AYAGIGLLGH AMTVADFAPM LGMLIGLGVG
IDYALFIVTR HRRGLKRGLS ATEAAVNAVA TTGRAVVFAG ATVCIALLGM LILRLGFLNG
VAVAASLTVV LTVAASVTLL PALLSYIGPR ALSRRERRRL AAHGPHPELP TGLAARWSAL
VERRPKLLGA FAVAVIAVLA LPTLSLHLGT SDQGNDPRTS TTRKAYDLLA EGFGPGVNGP
LTLVTRVDGA ADKLVLDGLD TTLRATRGVA SVTPVTYDTG GGTAYLTVVP ASAPQSQDTS
DLVDRLRNQV LPRAQTGTSL DIQVGGVTAG YDDFADVIVG KLPLFVGAVI GLGCLLLLVA
FRSLGIPLKA AVMNIAAVAA AFGVVVAVFQ WGWGSELLGL GRAGPIEPFL PVIMVSVLFG
LSMDYQVFLV SRMYEEWLET GDNRRAVRVG LAETSRVINS AAVIMISVFL AFVLSGDRVI
AMFGIALASA VALDAFVLRT LLVPALMHLL GAANWWLPAW LERRLPRISI EPPECRTAHE
RLGTVSMARL GEEQEHDVRD IPG
//
