ID   A0A176U6Q7_9FIRM        Unreviewed;       785 AA.
AC   A0A176U6Q7;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Glycosyl hydrolase family 2, sugar binding domain protein {ECO:0000313|EMBL:OAD88326.1};
GN   ORFNames=HMPREF2738_01709 {ECO:0000313|EMBL:OAD88326.1};
OS   Clostridiales bacterium KLE1615.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales.
OX   NCBI_TaxID=1715004 {ECO:0000313|EMBL:OAD88326.1, ECO:0000313|Proteomes:UP000077212};
RN   [1] {ECO:0000313|EMBL:OAD88326.1, ECO:0000313|Proteomes:UP000077212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KLE1615 {ECO:0000313|EMBL:OAD88326.1,
RC   ECO:0000313|Proteomes:UP000077212};
RA   Wen L., He K., Yang H.;
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC       {ECO:0000256|ARBA:ARBA00007401}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OAD88326.1}.
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DR   EMBL; LXPQ01000122; OAD88326.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A176U6Q7; -.
DR   PATRIC; fig|1715004.3.peg.1703; -.
DR   Proteomes; UP000077212; Unassembled WGS sequence.
DR   GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR040605; Glyco_hydro2_dom5.
DR   InterPro; IPR006101; Glyco_hydro_2.
DR   InterPro; IPR023232; Glyco_hydro_2_AS.
DR   InterPro; IPR006103; Glyco_hydro_2_cat.
DR   InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR   InterPro; IPR006104; Glyco_hydro_2_N.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR42732; BETA-GALACTOSIDASE; 1.
DR   PANTHER; PTHR42732:SF1; BETA-MANNOSIDASE; 1.
DR   Pfam; PF18565; Glyco_hydro2_C5; 1.
DR   Pfam; PF00703; Glyco_hydro_2; 1.
DR   Pfam; PF02836; Glyco_hydro_2_C; 1.
DR   Pfam; PF02837; Glyco_hydro_2_N; 1.
DR   PRINTS; PR00132; GLHYDRLASE2.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:OAD88326.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000077212}.
FT   DOMAIN          8..154
FT                   /note="Glycosyl hydrolases family 2 sugar binding"
FT                   /evidence="ECO:0000259|Pfam:PF02837"
FT   DOMAIN          171..273
FT                   /note="Glycoside hydrolase family 2 immunoglobulin-like
FT                   beta-sandwich"
FT                   /evidence="ECO:0000259|Pfam:PF00703"
FT   DOMAIN          280..477
FT                   /note="Glycoside hydrolase family 2 catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF02836"
FT   DOMAIN          698..778
FT                   /note="Glycoside hydrolase family 2"
FT                   /evidence="ECO:0000259|Pfam:PF18565"
SQ   SEQUENCE   785 AA;  89101 MW;  BBC29F66C4DCA19D CRC64;
     MDRTYITLNE NWKFHYGEVP EGWYKGYDDS AWTSVTLPHD WSVHMPFEQT NSSGTGYLSG
     GIGWYRVRFS LPEAYKGKRV RVVFDGIYKN SRIWCNSYHI GKRPYGYTQI SYDITDFVQF
     GAIDNEITVR VCHTDLADSR WFTGSGIYRK AYLVVEEQVH AVWNGVAFNV SRADEQSAAV
     CADAEIVNEL DERVIGTLTA SLKLCGSDEE SVVFARVPAA MEAHEKKTFY LNGMIGKPKL
     WSCESPSLYE LCISFEKEDE NVIVLDKERV GIRTFSFDAD QGFFLNGKET KFKGVCVHHD
     GGCLGAAMYR EVWLRRLLKL KEGGCNAIRC SHNPHMPELY DLCDELGLLM MDEAFDEWEN
     PKNKWSTGHN VYPPKHEGYA EDFPEWHERD LADMVRRDRN HPSIVMWSIG NEIDYPNDPY
     CHPLFETMTG NNDANKPAKE RQYDPNKPNA ERLSAIAKEL AAIVRTQDTT RPVTLAAAFP
     ELSSHIGFFD ALDVVGYNYK EHLYEESHKR FPDKPFLGSE NGGGYEQWCA VRDNAYISGQ
     FLWTGIDYLG EAHGWPIHGS SAGLMDLAGF EKPGFYRRKA FWSTEPFACI LTRPDDGDEH
     EWRPWNAHWN YTDGENVVVR VFTNVQKETI SLSIVGNDGE KSLHDGTYLE KEGCTEWRFA
     YEPGVLKAVC GEAECSIQTA GKAVELSANV WHAGETINKE EVMQIEVSLT DENGVLAAED
     LEITAEVIGG TLLGLENGDL ADLTPYCESH RKTHNGRLIV YVKPKEDVKV CISCPELDKR
     VWIEQ
//