ID A0A177BWS1_9PLEO Unreviewed; 372 AA.
AC A0A177BWS1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=C-3 sterol dehydrogenase/C-4 decarboxylase-like protein {ECO:0000313|EMBL:OAF98957.1};
GN ORFNames=CC84DRAFT_1223260 {ECO:0000313|EMBL:OAF98957.1};
OS Paraphaeosphaeria sporulosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Didymosphaeriaceae;
OC Paraphaeosphaeria.
OX NCBI_TaxID=1460663 {ECO:0000313|EMBL:OAF98957.1, ECO:0000313|Proteomes:UP000077069};
RN [1] {ECO:0000313|EMBL:OAF98957.1, ECO:0000313|Proteomes:UP000077069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP3s5-JAC2a {ECO:0000313|EMBL:OAF98957.1,
RC ECO:0000313|Proteomes:UP000077069};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KV441563; OAF98957.1; -; Genomic_DNA.
DR RefSeq; XP_018029323.1; XM_018183476.1.
DR AlphaFoldDB; A0A177BWS1; -.
DR STRING; 1460663.A0A177BWS1; -.
DR GeneID; 28766962; -.
DR InParanoid; A0A177BWS1; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000077069; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000077069};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..285
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 372 AA; 40872 MW; 01415BADBF383906 CRC64;
MAAAKAPVPS LGHVLVVGGC GFLGSHIVSL IAKRHPQTRI SVLDLRTTAN RHASPTVSYH
DGDITDLHAL EALFAQLRPD AIIHTASPHF HLPPAVHDKV NVEGTKNLLA AAQETGVKAF
VYTSSASVIL GPETELVNAN EDWPMVTGAA QPEHYTSTKA YAETAVLAAN RTPASFLTCA
IRPAGIFGEG DVQLLPPMLS AFRKGQTKYQ VGANDNLFDF THVENVAYGH LLAVQALLYS
HKMLPTVPLD TERVDGEAFF ITNGQPVYFW DFARAVWHEA GDRRPLSAVW KLDRDFAMGV
GAILENLFWV LGRTPNITRK QVRYSTLSKY HDISKAKRRL GYAPLVQLDE GVRRGVRWQL
ENEAKAAQKK DQ
//
