ID A0A177CEL2_9PLEO Unreviewed; 337 AA.
AC A0A177CEL2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:OAG05239.1};
GN ORFNames=CC84DRAFT_1122346 {ECO:0000313|EMBL:OAG05239.1};
OS Paraphaeosphaeria sporulosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Didymosphaeriaceae;
OC Paraphaeosphaeria.
OX NCBI_TaxID=1460663 {ECO:0000313|EMBL:OAG05239.1, ECO:0000313|Proteomes:UP000077069};
RN [1] {ECO:0000313|EMBL:OAG05239.1, ECO:0000313|Proteomes:UP000077069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP3s5-JAC2a {ECO:0000313|EMBL:OAG05239.1,
RC ECO:0000313|Proteomes:UP000077069};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV441553; OAG05239.1; -; Genomic_DNA.
DR RefSeq; XP_018035604.1; XM_018175634.1.
DR AlphaFoldDB; A0A177CEL2; -.
DR STRING; 1460663.A0A177CEL2; -.
DR GeneID; 28759120; -.
DR InParanoid; A0A177CEL2; -.
DR OrthoDB; 5305445at2759; -.
DR Proteomes; UP000077069; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF504; GLYCEROL 2-DEHYDROGENASE (NADP(+))-RELATED; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000077069}.
FT DOMAIN 39..306
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 72
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 132
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 101
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 337 AA; 37103 MW; D8403CBF72C73754 CRC64;
MNPSLANFIL KLSPKDILNP TPTMNTAIPL NTGATIPALG LGTWQSAPGE VKKAVIHAIE
GGYRHIDCAF CYQNEDEVGE ALQDVISRGI VKREDLFITS KLWCTFHTRA EEGLQKSLDL
LKTPYVDLYL MHWPVPMNPK GNHPLFPKLE DGSRDIDHSI THIDTWKNLE ALYKAHPEKV
KAIGVANYSV KYLEKLLAQS TITPAANQIE NHPLLPQQEV VDFCRSKNIH ITAYSPLGST
GSPLFKDAGV LDVAKKHDVG PGTVLLSYHL ARGSSVLAKS VTPSRIDENR KLITLDEGDM
QALEAIHKKN GVQRFVYPPF GVNAGFPDKT EGIDLSG
//
