ID A0A177CFX5_9PLEO Unreviewed; 654 AA.
AC A0A177CFX5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Probable Xaa-Pro aminopeptidase P {ECO:0000256|ARBA:ARBA00020658};
DE AltName: Full=Prolidase {ECO:0000256|ARBA:ARBA00032413};
GN ORFNames=CC84DRAFT_1164108 {ECO:0000313|EMBL:OAG05630.1};
OS Paraphaeosphaeria sporulosa.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Massarineae; Didymosphaeriaceae;
OC Paraphaeosphaeria.
OX NCBI_TaxID=1460663 {ECO:0000313|EMBL:OAG05630.1, ECO:0000313|Proteomes:UP000077069};
RN [1] {ECO:0000313|EMBL:OAG05630.1, ECO:0000313|Proteomes:UP000077069}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AP3s5-JAC2a {ECO:0000313|EMBL:OAG05630.1,
RC ECO:0000313|Proteomes:UP000077069};
RG DOE Joint Genome Institute;
RA Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT ascomycete fungi.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KV441552; OAG05630.1; -; Genomic_DNA.
DR RefSeq; XP_018035995.1; XM_018178413.1.
DR AlphaFoldDB; A0A177CFX5; -.
DR STRING; 1460663.A0A177CFX5; -.
DR GeneID; 28761899; -.
DR InParanoid; A0A177CFX5; -.
DR OrthoDB; 869at2759; -.
DR Proteomes; UP000077069; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:OAG05630.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:OAG05630.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000077069}.
FT DOMAIN 49..172
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 362..581
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 592..653
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 654 AA; 73009 MW; 67FAC3162037CC7E CRC64;
MLLSRSLLRT HATPAAHAAR RLPFPCQRAF HASAIRRLLD MEKVNTSERL AELRKLMQER
QIDVYMVPSE DSHQSEYIAP CDGRREYISG FSGSAGYAVI THEKAALSTD GRYFNQAEKQ
LDSNWELLKQ GLQDVPTIQE WTADQVAGGK VVGVDPTVVT AADARKLADK IKKKGGDYKA
VDENLIDLVW GRKRPSRPSE KVIVQPVQHS GKSFDDKIAD IRKELEKKKS LGFVASLLDE
VAWLYNLRGS DIPYNPVFFS YAVVTPTEAI LYVDESKLTP EAREHLGDKV TVKPYDAIFS
DLKALSAEAF DANSEAAENK KFLTSNRASW ALNKALGGEE RVDEVRSPIG DAKAVKNEVE
LEGMRNCHIR DGAALSEYFA WLEDQLINKN ATLDEVDGAN KLESIRAKHD LFMGLSFDTI
SSTGANAAVI HYKPEKPLAS VIDPNAIYLC DSGAQYRDGT TDTTRTLHFG EPTETEKTAY
TLVLKGHIAL ERVKFPKGTT GFAIDALARQ FLWAEGLDYR HGTGHGVGSF LNVHEGPIGI
GTRVSYSEVP LSVGNVVSNE PGYYEDGKFG IRIENMVLVK EVETKHKFGD KPYLGFERVT
MTPHCRKLVD MSLLSEAEKT FINEYHQEIF DKTSKFFEND PLTMAWLERE TAPY
//
