ID A0A177EH11_9MICR Unreviewed; 791 AA.
AC A0A177EH11;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ubiquitin-protein ligase E3 A {ECO:0000313|EMBL:OAG30690.1};
GN ORFNames=NEIG_00202 {ECO:0000313|EMBL:OAG30690.1};
OS Nematocida sp. ERTm5.
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX NCBI_TaxID=1805481 {ECO:0000313|EMBL:OAG30690.1, ECO:0000313|Proteomes:UP000077089};
RN [1] {ECO:0000313|EMBL:OAG30690.1, ECO:0000313|Proteomes:UP000077089}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ERTm5 {ECO:0000313|EMBL:OAG30690.1,
RC ECO:0000313|Proteomes:UP000077089};
RA Reinke A.W., Balla K.M., Bennett E.J., Troemel E.R.;
RT "Identification of microsporidia host-exposed proteins reveals a repertoire
RT of large paralogous families and rapidly evolving proteins.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAG30690.1}.
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DR EMBL; LTDK01000174; OAG30690.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A177EH11; -.
DR VEuPathDB; MicrosporidiaDB:NEIG_00202; -.
DR OrthoDB; 5471864at2759; -.
DR Proteomes; UP000077089; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:OAG30690.1};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 480..791
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 759
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 791 AA; 91333 MW; 76A983FFACE01E32 CRC64;
MKNKESKQNL ELVEKLKKQI IYGCGGGLCI GIFCKLSDIE SISDEIVELL LEYDDYFTCE
SLYFIHGRAA YTAQKESKYY STRIGLHPNM SVALLPQAVK KQMNELNIIK NSAGKIISHI
NTARNILKYF YMSLKSTGQT SYSCSPIMHR EFGVPLSVVQ ENFLLLPKPY TDENSKKEYL
RMELARVIHK KKAKTEAIVL QGLFYHELNR LKAGYSIHTT IRIIKLFNAV KECVKFEKKY
FIRFLESIEM LCQVTKAENI LCMDRCNKIL GGFSYKKVPE CGFKEHEEFP VITRPIPVKE
ISSRVIEECP LCNETLKDCE YPHCDSLCYV SNKLCINELI DLIKSLIIVI DNTSVINMRE
GTLLLAILKS LKGLYEFSVE TGLIHHSMFV NRRFSRLLNY KAEVRYHKEG SHSIFDFPFI
LDMPAKSDLI QIENTDRMKA ELQDAFFRSM FEGQVDPYLN LEVGRESVVE DSLRLLESLE
EGTAWKQLKI KFVGEDGIDS GGIKKEFFQI LSQKTLGEWD IFRESNGCLW FNHFSDEELE
KRKTQYKILG SILGLAAYNG AVLCFYFPQV FYKRLLGYSG TFEDLKTVEP TIYQTLTQIK
EMSPEEVSAL SLEYTLDGKV HEVSHRNIEE FTQVYCKELL ETRLEPAFAL IKEGLWRICG
DTFIKSLLPC ELSILIGGME CINMEELERY TIYNGYRRDS ELIQSFWEIF KQYDITMQKK
FLRFVTGTDR APSGGLSRMA LVFMRNGGDT DRLPSSQTCF NTFLIPEYSN KKKLKEKLDL
AISNTEGFFL L
//
