ID A0A177R0N5_9PROT Unreviewed; 2126 AA.
AC A0A177R0N5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Diguanylate cyclase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AYO46_04935 {ECO:0000313|EMBL:OAI52706.1};
OS Betaproteobacteria bacterium SCGC AG-212-J23.
OC Bacteria; Pseudomonadota; Betaproteobacteria.
OX NCBI_TaxID=1799662 {ECO:0000313|EMBL:OAI52706.1, ECO:0000313|Proteomes:UP000077532};
RN [1] {ECO:0000313|Proteomes:UP000077532}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SCGC AG-212-J23 {ECO:0000313|Proteomes:UP000077532};
RA Choi J., Stepanauskas R., Howe A.;
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAI52706.1}.
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DR EMBL; LSTF01000033; OAI52706.1; -; Genomic_DNA.
DR Proteomes; UP000077532; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 4.
DR CDD; cd00156; REC; 1.
DR Gene3D; 3.30.450.40; -; 4.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 7.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 6.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF13185; GAF_2; 4.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF13426; PAS_9; 7.
DR Pfam; PF00072; Response_reg; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00065; GAF; 4.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00086; PAC; 7.
DR SMART; SM00091; PAS; 4.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55781; GAF domain-like; 4.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 7.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50113; PAC; 5.
DR PROSITE; PS50112; PAS; 3.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000077532};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 18..134
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 220..272
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 269..313
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 466..518
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 941..993
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1165..1209
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1363..1415
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1412..1457
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 1486..1536
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 1729..1862
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 1871..2125
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
FT COILED 829..869
FT /evidence="ECO:0000256|SAM:Coils"
FT MOD_RES 70
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 2126 AA; 237569 MW; E806B8EC1A34D483 CRC64;
MDNEKFVTRR RQWRETVSIL LVEDDTMFAE LVRAQLRRMP WVQARLELAG TLRAALEKLA
AEPFGLVVTD LNLPDSKGLD TLGALSRAGD QPILVLSGDP DPAVRAGALD GGAYDFLSKD
NLSAAALERL VRLASIQANT FSLVREGEER FRSLIRLSTE SYWESDAEHR VVKLELGTTR
RATLNPDQMG KTRWDLPSTW PDAAGWAAHR ATMDARRPFS DFEFARREAD GVERWRSISG
EPIFDAAGTF VGYRGAGRDV TERKRAEEEL RRFRLAMDES ADIIVLIERA SMRFVDVNQT
ACNLLGYSRE ELLAMGPHDV LPFGREQLEK SYDEFIADPS HTTGMSSYYR CKDGSTLPFE
STRRVLRSGS GWIIAAVSRD IRERVAAEKA LHESSERFRS LNALSSDWYW EQDSEFRLTF
MSSIEKLGLD PAKYLGGRRW DQPALNLGEA DWARHRAQLE RHEPFHDFEM ERSGAEGGSV
WLSLSGEPMF DEAGRFTGYR GVGRDITARK REERLQSLEH QVTRCLADAD TASEALQGVL
RAICETEMWD CGRYIIADRD ARVLRTVEAW TAPRSGIERL VERSREAPFE PGDGLNAQVL
QSGEPIWVAD IRRDPRARQI VFGADSGMRG AFAFAVTVGG SPIGVLKFNA REVRSPDRRF
LQAARVIGSQ VGQFLQRKRA EDDAGRLTRM NVALAAANEA ILRAKTQQEV FERACQIAVE
AGDFLVGTVF VIEPKSRKLV RAAVSGRAAE RVHPVQPTFD TSDPSGAGLL GEACRTGRLV
ISNDYAADRR ASGAGGTYQV GSAAVFPLPV DGELFGVFGL QHAQRGAFSE ELTALLQRLA
DNIAFALENF RANQRRRAAK RKLAESEQRF RSLTGLSSDM YWEQDEEHRF TALSDSGPKS
LNSWRRQNML GKHRWDQRYF NMTDADWDAH RALLATREPF FDLELGRFNE AGEKVWVTVS
GEPFFDEAGK FRGYRGIGKE ITERKRAAQL RVLEHSVTRS LAEANGVSEA LRGAMQAICE
TEGWECGRFY VADAKPDVLR LAESWGLGND SIQRYLAGMR DITYAFGTGL TGRVWQSGEP
LWVRDIHNDS RVAQANLARE ADIHGAFIFP ALSEGRTMGV LAFNSRDIRQ PEEGLLQAIR
VIGSQIGQFL QRKEVEASRR RDEEELRRFR AAMDTSADMI LLIDRETLRY VDVNSTTCQK
LGYSREEMLL LGPLNLTPIP RADLERTYDE MIASGETTRL LSKQYRKQGA PIPVEVLRRA
VRAGERWIIV AILRDISERL AADEALRKSE ARFRSLTNLS SDWYWEQDSE FRFTKFEGKG
AVAEYSPSAV VVGKRIWEVP GIVEGSVDWD AYRAGVERHE SFRNLQYAYR GRSGSTYYVS
ADGEPVFDDA GAFIGYRGTS RDVTRQRRDE EELRRFRAAM DMSLDAIYLT DRPTMRFVDV
NKLACKFLGY SREQALGLGP ADALPIAREQ LEREYDEVIA TGSKGVRVEY AYTGKDGRRG
WSELHHRALR EGERWIIVTV SRDITERKLA DQRQTQYARH QERIARFGQS ALAKREPSDL
MREAVQNVLE GLNADAVAYF EPATGGEELV LHALVGAGEG RDGAAVKCGA SNPVQRALRS
GEALVVDGAE LEFDWAAGLH SAAVIPVRGE RRPRGALCVC YRSANAFAAD ALNFVEAAAS
VLSAGLQRID SESRLAFLAQ FDSLTGLPNR ALLADRFSQM IVLAKRRNAS LSVLFIDLDE
FKMVNDTLGH SGGDQLLKEV AVRLQSCVRS GDTVARISGD EFAVILADMA RQEDGALVAQ
KIIDRLAAAF EIHGQEVFIS ASLGIAAYPG DGADAETLIG AADAAMYRAK QAGRNNFQFF
TAEINQRTRS RAQLGVELRR ALEREEFVLY YQPKVELANR RFYGAEALIR WKHPERGLVS
PAEFIPVLEE TGLIVPVGEW VLKRACEDLK AWKAAGLDVG PVAVNLSARQ FRLQDLDQRL
KAVVAEAGID PSLIELEITE SQLMVDPDHA IRVMRSLCDA GMRIAIDDFG TGYSSLAYLT
RFPVGALKID RSFVADVNKD PNDATIVRTI IEMAHSLGFT VVAEGVETEE QATFLRLLRC
ERAQGYLFAR PMPAADLVNR LSKKAN
//
