ID A0A177YDN9_9NOCA Unreviewed; 4508 AA.
AC A0A177YDN9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Carrier domain-containing protein {ECO:0000259|PROSITE:PS50075};
GN ORFNames=A3K89_23150 {ECO:0000313|EMBL:OAK53571.1};
OS Rhodococcus kyotonensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Rhodococcus.
OX NCBI_TaxID=398843 {ECO:0000313|EMBL:OAK53571.1, ECO:0000313|Proteomes:UP000077519};
RN [1] {ECO:0000313|EMBL:OAK53571.1, ECO:0000313|Proteomes:UP000077519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KB10 {ECO:0000313|EMBL:OAK53571.1,
RC ECO:0000313|Proteomes:UP000077519};
RA Jeong H., Hong C.E., Jo S.H., Park J.M.;
RT "Genome sequence of Rhodococcus kyotonensis KB10.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAK53571.1}.
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DR EMBL; LVHI01000018; OAK53571.1; -; Genomic_DNA.
DR RefSeq; WP_068427237.1; NZ_LVHI01000018.1.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000077519; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd17643; A_NRPS_Cytc1-like; 1.
DR CDD; cd19543; DCL_NRPS; 1.
DR CDD; cd19540; LCL_NRPS-like; 3.
DR Gene3D; 3.30.300.30; -; 4.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 4.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 4.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF00550; PP-binding; 4.
DR SMART; SM00823; PKS_PP; 4.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR SUPFAM; SSF47336; ACP-like; 4.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 4.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000077519}.
FT DOMAIN 162..236
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1716..1791
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2794..2869
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3863..3938
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 4508 AA; 482676 MW; 3EB845C3CC29C42D CRC64;
MGELYLAGVQ LARGYYGRPD LSADRFVADP FDVGGRLYRT GDLVRWTASG ELEYIGRSDF
QVKLRGLRIE LGEIESALLT DDAVAQAVVQ VRQDQLVAYV VPTSGVTVDV SSLLQSVGAL
VPEYMVPAFV LVLDELPLGP SGKLDRKALP DPVFESTAEF RDAETDVERV LSDVFAEVLG
LDRVGIDDSF FALGGDSIVS IQLVARARAR GVVIAPRDVF EQKTVAGLAS VATSDDVVGK
AVLEELDGGG VGSMPLMPFA QLMIERAGSG ARRNDPELGG AHDRFVQTVT LELPAAIDRQ
GIARTVAAVI DKHDGLRATL VENSEGWSLE ISAPGTVPAD GLIDRVEVDP DIDEAAVLSI
ASDAVNESMS HLDPRSGRML RFVWIDFGPR RSGRLVVVAH HLVVDGVSWR ILVPDFVAAW
AQVSLGNDPV LPEVGTSERR WAHALHEEAH SADRIAELPV WKAISSTDDP VLGDRPFDPA
IDVSSTVERV SAVVPADVTK ALLTAVPDAF RGGVNDGLLT ALAVAVNRWR AARGVDAPST
LVQLEGHGRE EELVPGADLS RTVGWFTSVY PVRLDLSGVD TAEALAVGGE MARAVKAVKE
QLLAIPDKGM GYGLLRYMNR ETGAELTALS DGQISFNYLG RISTGELPEG LDGWVPASDF
DDLVVVGDAD MPANKTVDIN AIVRGVGDES ELAATFAFPT GAIGRGDVQE LADLWVAALV
ALAAHVTDGS AGGLTPSDVP LAQVTQRDID VVETQYPSTT DIWSLSPLQS GLLFHAKLAG
SDLDVYTMQM VLTLTGDVDA QRLRGAAQAL LDRYDNLRTA FVTTADGSSV QVVVQDVTVP
WTEHDLSDVP EAERTAAYER LRAEEQATQF DTAAAPLVRF TLVKLSDGEF RLLFANHHIL
IDGWSMPLLM KDLLVLYAVH GDAGTLPRVP SYRTFLSWID RRNHVESAAV WARALEDAPE
PTLLAPSAAG REISSRAGAV ELAMSAELSA SLSALGARLG VTVNTLVQAA WGMLLSASTG
RDDVVFGATV SGRPASLPGV ESMVGLFINT LPVRVRIDSS ESLESALTRL QSEQADLLDH
HYLGLTDIQR AAGVGTLFDT LTVFESYPVD EAGLAAQASD IDGMAVTGVE SNDSTHYPLT
LLIVSDDRIR LTLKYFEDLF ERDQVTAMLA RVQRILEAIA ADSTRRVGDV DLLDAAERAL
VLDTWNDTEH AVDDALLLDA FHAQVERTPD AVALTFEGES LSYREFSDRV GRLARYLVGE
GVGPETTVAI GIRRSFDLLV AIYAVVEAGG AYVPVDPEQP TERIEYIVDT AAAALVLTTG
RDGLDVGAGV RIRHLDQLDL DGYEGGRLTE SERPATTDGS AYVLFTSGST GRPKGVTIGH
RAIVNRLEWM QAEYALTDSD VVVQKTPVTF DVSVWELFWP LQVGARMVIA RPDGHRDPAY
LAQLIVSESV TVAHFVPSML AVFTAEPSAR TATSLRWVFA SGEALPSATA ASLTQAVPSA
RMINLYGPTE AAVDVTYHEF TSADVSGVPI GKPVYNTRVY VLDNALRPTP VGAEGELYLG
GVQLARGYAS RPDLTADRFV ANPFGEGRLY RTGDVVRWNG DGELVYVGRS DFQVKLRGQR
IELGEIESAL VAADSVAHAV VAVRDDRLVA WIVFASGLDS DSGAVESVLA DASERLPSYM
VPSAVVVLDD LPLTSSGKLD RKALPEPEVA AAEYRAPGTP IEQAVADVFA DVLGAERVGL
DDDFFSLGGN SLIATQVVAR LSAALDAQVP VRALFDATTV GALARRIEDH VGAGARAALV
AGPRPERIPL SLAQQRMWFL NRFDTESSVN NIPVAIRLTG SLDRDALRQA ISDVVARHET
MRTIYPEFDG VGHQVVLPAS EVEVDLTPVT VSEHDVLSTV VDIVSGGFDV TREVPVRVRL
LSLQEDDHVL VFVVHHIASD GFSMRPLTTD VMVAYASRAA GDVPAWAPLP VQYADYAVWQ
REVLGTEDDA SSIASQQVAY WTRQLSGLAD QIELPFDYAR PTVATNRGRT TSFTVSPELH
HALDVVAREN NSTLFMVVHT ALAVLMSRLS ASEDVAIGTP VAGRGEAELD DLIGMFVNTL
VLRTQVEPST SFRDVLAHAR ETDLSAFANA DVPFERLVEV LDPERSQSRH PLVQVVLAFQ
NLGRTALELP NLSVEALEFD AGIAKFDLQF TFEEATDSAG ALGGMTCYIS YATDLFEEST
VDRFGRQFLA VLSGVVADAS VAVGDVDIVD ADTRDRVLTQ WSSSGPDVSV GADTLIDRFD
AVVASHPESV AVRFDGVSLT YAELDARVNR LARRLIAAGA RPDSLVAVAL PRSADLVVAL
LAVVKSGAGY LPVDPTYPAE RIEFMMSDAA PVAVVTTPEV SAAESMAGVR GADIPVVDVT
QDDPDAWSSK PVTDAERRAP LSADNLAYVI YTSGSTGRPK GVLIPHSTVV RLMDNTDGSF
GFDETDVWTM FHSYAFDFSV WELWGPLLYG GTLVMVDYFT SRSPEAFREL LVAEGVTVLN
QTPSAFYQLA ELDRAGAANA GELSLRYVVF GGEALEPRRL EGWFARHGDG SESGPLLVNM
YGITETTVHV SFRALSAASA GSASVIGAPI SGLGVYVLDT RLQPVPVGVA GELYVSGGQL
ARGYLGRADL SSVRFVANPF GEGRLYRTGD VARWVEKADS SAELVYLGRA DDQVKVRGFR
IELGEVEAAV SAQPGVTAAA VIVREDTPGA TRLVAYLVGT ADVEAVRSGV ATLVPEYMVP
SAFVVLGEIP LTVNGKLDRR ALPVPTTAAV EFRAPSTPLE EIVAGVFADV LGVGRVGVDD
DFFALGGNSL IATQVVSRLG AALDTQVPVR LLFEASSVGD LAGRVESSVG AGGRQELVAR
ERPQHVPLSL AQRRMWFLNR FDSASTAYNI PMALRLSGEL DEDAFAEAIG DLVARHETLR
TVYPNTDSGP AQKVLTPEQA GIALTVESVD AAAVTEKVLA LAATQFDVTS EVPVRITLFR
IDGDVPEYVL AMVVHHISAD GSSAVPVMSD LMTAYGARTH GQSPDWAPLP VQYADYALWQ
RDVLGDEDDP TSVGARQLEY WKSELADLPD QLTLPIDKPR PADQSFRGDR VEFAVPATTH
AALQDLAREN NATVFMAVHA AFSVLLSRLS GMTDIAVGTP IAGRGEAVLD NLVGMFVNTL
VFRLDVTGER SFVDLLATAR ETDLQAFANA DVPFERLVEV LNPARSTARH PLFQVGFSFQ
NVARSSLELG DLTVSAVDAD SGNSQFDLHL ILADHYDDDG APAGFEAIMT YATDLFERGT
VETIVERFVR VLESVTQAPS TAVGDITILD DDERDALVSG WNDTGHDTDS SATLVDLFDA
QVRRDPAATA LVYEGESLSY GDFDARVNRV ARALVERGVG PESLVGLAIR RSVDLLVGMY
AIVKAGGAYV PIDPDQPAER VKYILDVADP VCVITAGEDI GSGSVALSEL ENACSDASPI
APEERLLPLR PDNTAYVIFT SGSTGKPKGV AVTHGAIVNQ LLWKHAEFGM DATDSVLLKT
VATFDLSVWE FWSALTSGGS IVVATADGHR DPDYLLALMR DHAVTTLHAV PSMLSMLTTV
AGGTLPTTLR RVLAIGEALP PATARAFRRH NSAELFNLYG PTEAAVSITS HLVTDADVTS
VPIGRPEWNS EVLVLDSRLQ PVPVGVSGEL YLAGAQLARG YHGRADLTSD RFVANPFSSG
QERSLRSDQT DGTRMYRTGD VVKWTAAGEL DYVERVDFQV KVRGYRIELG EIETALRDQD
AVREAAVTVH NDGRTGDQLV AYVVPAAGEF DVASSRAALT SSLPSYMVPS AYVVLDALPL
NTNGKLDRKA LPKPEVVARE FRAPTNPVEE VVVRTLADVL GLDRIGLDDD FFELGGNSLI
ATQVVSRLGA ALDTQIPVRA LFEASTVEAL AARIQPLVGG GARVPLVARE RPAAIPLSLA
QQRMWTLNQV DPESAAYNIP AAVRFSGALD TDAFAAAMAD VVERHEVLRT TYPDSETGPI
QVIGPVADAL PDLTPISVSE SEVYERVGAV LGAGFDVTTE VPVRAALFSL GESEYVFALV
AHHITADGFS MRPLIRDVML AYTSRAAGDA PQWAPLPVQY ADFTLWQREV LGSEDDPDSA
ISTQLAYWNR ELAGLPELLP LPTDHPRPPR QSTIGAAYEF SFGPEIAHRL EKTAREHNAT
VFMVVHSALS VLLARLSGTD DIAIGTPTAG RGEEALDDLV GMFVNTLVLR THVDGGISFA
DLLFRTKDTD LAAFGHADVP FERLVESMGR TAGGRSGSSA FSPLFQVMLT FQNAVSGTFA
LPGLEVSTLA ADEDQAKFDL QLTAIEQFDD SGALTDVKAL FNYATALFTR STVEKFADRF
LRILDAVTQD PSVTLRSIDI LSEAERAAFA PKRAAKTVDD LPGLVSEAAA ASPASVALTH
DGTEVTFEEL NTKIGAVSKA MGATLKPEAL ITVALSQLVP GILPALGAEG YASLIASMIE
TASSVAES
//
