ID   A0A178BAH9_9PLEO        Unreviewed;       371 AA.
AC   A0A178BAH9;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN   ORFNames=IQ06DRAFT_207666 {ECO:0000313|EMBL:OAL07275.1};
OS   Stagonospora sp. SRC1lsM3a.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Massarineae; Massarinaceae; Stagonospora.
OX   NCBI_TaxID=765868 {ECO:0000313|EMBL:OAL07275.1, ECO:0000313|Proteomes:UP000077206};
RN   [1] {ECO:0000313|EMBL:OAL07275.1, ECO:0000313|Proteomes:UP000077206}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SRC1lsM3a {ECO:0000313|EMBL:OAL07275.1,
RC   ECO:0000313|Proteomes:UP000077206};
RG   DOE Joint Genome Institute;
RA   Zeiner C.A., Purvine S.O., Zink E.M., Wu S., Pasa-Tolic L., Chaput D.L.,
RA   Haridas S., Grigoriev I.V., Santelli C.M., Hansel C.M.;
RT   "Comparative analysis of secretome profiles of manganese(II)-oxidizing
RT   ascomycete fungi.";
RL   Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; KV441705; OAL07275.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A178BAH9; -.
DR   STRING; 765868.A0A178BAH9; -.
DR   InParanoid; A0A178BAH9; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000077206; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000077206}.
FT   DOMAIN          14..284
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   371 AA;  41119 MW;  30B9D193D85C1F2F CRC64;
     MSRQQDQSSL GKVVIVGGCG FLGSHIVNYI VERHPKTQIA VLDLRTSSNR NNSSNVSYHD
     GDITDVAAMT AFFAQTRPDA VIHTASPHFD LKPEIHDKVN VGGTKTLLKA AQEAGVKAFV
     YTSSASVILG ASEPLINADE RWPIVAGAAQ PEYYTTTKAF AETAVLEANR KPEKFLTCAI
     RPAGIFGEGD VQLLPKMVTA YRKGQTKFQI GDNNNMFDFT YVGNIAHGHV LALIALLETH
     RMLPTAPLDH ERVDGEAFFI TNGEPVYFWD FARAVWHEAG DRLPLSKVWH LSADTAWAIG
     TVLEWAFWML GKTPNLTRAQ VRYSSMNKYH SISKARTRLG YSPIVRLDEG IKRGVQYILA
     QEKKESEKKG Q
//