ID A0A180G244_PUCT1 Unreviewed; 974 AA.
AC A0A180G244;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=PTTG_29732 {ECO:0000313|EMBL:OAV86776.1};
OS Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV86776.1};
RN [1] {ECO:0000313|EMBL:OAV86776.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV86776.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAV86776.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV86776.1};
RA Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA Young S., Zeng Q., Fellers J.;
RT "Comparative analysis highlights variable genome content of wheat rusts and
RT divergence of the mating loci.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV86776.1}.
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DR EMBL; ADAS02000821; OAV86776.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A180G244; -.
DR STRING; 630390.A0A180G244; -.
DR VEuPathDB; FungiDB:PTTG_29732; -.
DR OrthoDB; 168255at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 769..785
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT COILED 575..602
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 974 AA; 108984 MW; 54D52A2B8143F9D3 CRC64;
MTTPMYPTKA PEVNEDQTTS KKFCEIFKNL EPCPKGTLRI FEREKGEFYT CYGQDAQYIA
TQFYRTNTVL RFIGSKSNGE QGLPSCSLSR TGAITFLREC LTSRQMRIQI YRSDQPSAKS
SSNWSLAVQA SPGNLEPLAD LLFSNTDILS SPVIASLWVK GNPGSSSGRI MGVAFADTSV
RTLGLSEFPE QEDGWGNTES LIIQLGIKEA IIASATSTKN SSDSSQNSEY QQLIEVLERC
GVVVTERKRV EFTLKNVEQD INRLLSGDRQ LAALPQFEMK TALAALNPLL NYLAILDDPS
NHSAYKFITH DLGQFMRLDA SAVRALHLFP NPTSIGGGGK NMSLFGLLNR CKTSQGTRLL
GRWLKQPLVN LHEIEQRQTL VGIMFQDGLV RQALQEDHLK AMPDLTRISK RFIQGAGSLE
DVVRVYQAVV KLPEILEALT KVDGIETDNK EEAKDLLNVI YCVPFQECVT NLAQYVEMVE
TTVDLDELEN HQFIIKPDFD DDLRELKNAL VQNRQQLDDE HQRVAEDLGM GTDSKVLHFE
NHQVYGYVFR LTRKEAGVIR SKKNYIELSN RNNGCHFTTK TLKELNNELK DFTQKYQRKQ
SSLVKEVVSI AASYCPILEK LNEIIAHLDL IVSFAHVSLN APMTYTRPKM YALGEGDVSL
KGCRHPCLEV QDDINFIPND TLMERDKSSF HIITGPNMGG KSTYIRQIGV AALMAQLGCY
VPCAEASLPV FDSILARVGA GDSQTKGIST FMAEMLETAV ILKSATPNSL IIIDELGRGT
STYDGFGLAW AISEHIAVEI KALTLFATHF HELTSLDKEV EHVKNYHVVA HVEKKSAAGV
SSSDITLLYK VEPGFSDQSF GIHVAEMANF PEDVLKLARR KAEELEYFGD EKSVDPEKKA
PSKEAVEAGT ALVTQMLQQW INQDKTSKNS EKMDVDEDKL KLEFKVNCLK ESFQTFLPQL
EQNSWIRDVL MNSY
//
