ID A0A180GJY2_PUCT1 Unreviewed; 723 AA.
AC A0A180GJY2;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=GTP-binding protein LepA {ECO:0000313|EMBL:OAV92911.1};
DE Flags: Fragment;
GN ORFNames=PTTG_09744 {ECO:0000313|EMBL:OAV92911.1};
OS Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV92911.1};
RN [1] {ECO:0000313|EMBL:OAV92911.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV92911.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAV92911.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV92911.1};
RA Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA Young S., Zeng Q., Fellers J.;
RT "Comparative analysis highlights variable genome content of wheat rusts and
RT divergence of the mating loci.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. LepA subfamily.
CC {ECO:0000256|ARBA:ARBA00005454}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV92911.1}.
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DR EMBL; ADAS02000057; OAV92911.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A180GJY2; -.
DR VEuPathDB; FungiDB:PTTG_09744; -.
DR OrthoDB; 5473535at2759; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd16260; EF4_III; 1.
DR CDD; cd03709; lepA_C; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.2570; Elongation factor 4, C-terminal domain; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR HAMAP; MF_00071; LepA; 1.
DR InterPro; IPR006297; EF-4.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR038363; LepA_C_sf.
DR InterPro; IPR013842; LepA_CTD.
DR InterPro; IPR035654; LepA_IV.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR01393; lepA; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43512:SF7; TRANSLATION FACTOR GUF1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43512; TRANSLATION FACTOR GUF1-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF06421; LepA_C; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00022792};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 69..271
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 101..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OAV92911.1"
SQ SEQUENCE 723 AA; 79839 MW; 7FE17D4F48398138 CRC64;
RRTNFSNAAV LRRARPGKQK MIRTTTRTIR PRIRVSTSYQ QYRTFHATKP PPAAAEQSTP
INLSSFTPDL IRSFSIIAHI DHGKSTLSDR LLELTRTIPQ QPLSSASSSS GHANPNQGPA
RNQQVLDQLA VERERGITVK AVAVSMFYTS QSGITYLLNL IDTPGHVDFT TEVLRSLSAT
QGAILLVDAT QGVQAQTLAV LQAARRRRLT ILPVLNKLDL PSAEPEKVAL QVGRLLDDSR
PDEDIIKISA KTGQGVEDLL EALVAKLPPP VADPNRPLRA FVFDSWFDHF QGVVSLVSIA
DGRIQKGDKI KSFKTGKTFQ VADCGIMHPH QLSLPSGLHA GQCGWLTCAM KNAKEAILGD
TFYAAKTPLT EIEPVNRSIE TRQSMVFAGL YPIDSNAFDR LADAIQRLVL NDRSVTVNKE
SSVALGQGFR LGFLGTLHMD VFRQRLNDEY ASEVIITRPF VPLQLVSKGK TSMIEKPIDF
PNVRNRADGV KVFERIIDGT IIVPDRFTGP VMELCSSHRG IQQTFEYIAA PSSETKKDGE
VVLEGDERWV EIRYKIPLSE IVTTFHSTLK SLSSGYATFD YETPEGDEGF VEADLVRVDI
VVNKSSPIDA FATVVHRDHA LREAKAILSR LKSVIPRQQF EIALQAAIGS KIIASERITA
VRKDVTAGLY GGHYERKMKH LQKQKEGKKK LRSLSIGKVE IPQEAFSAVL SVDGKVAASN
KRK
//
