ID A0A180GLV7_PUCT1 Unreviewed; 1645 AA.
AC A0A180GLV7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PTTG_07731 {ECO:0000313|EMBL:OAV93484.1};
OS Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV93484.1};
RN [1] {ECO:0000313|EMBL:OAV93484.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV93484.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAV93484.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV93484.1};
RA Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA Young S., Zeng Q., Fellers J.;
RT "Comparative analysis highlights variable genome content of wheat rusts and
RT divergence of the mating loci.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV93484.1}.
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DR EMBL; ADAS02000050; OAV93484.1; -; Genomic_DNA.
DR STRING; 630390.A0A180GLV7; -.
DR VEuPathDB; FungiDB:PTTG_07731; -.
DR OrthoDB; 4819765at2759; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113:SF369; CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE; 1.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 935..1060
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1246..1486
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 13..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 130..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 832..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1104..1143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1157..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1572
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1626..1645
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..226
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..897
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1552..1572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1645 AA; 175404 MW; 12D0076CBDB3AC9A CRC64;
MSLPVIPDEL LAALAHEPPP PPPATNRNRM KENKETIWNR FGFSSAAASP TQRKQKPAAY
HPQTTPAARA RASFSFDHYI KTNERTRSRF IGSEIINGIF SNSTSHHQTI DQPAARSSSI
NASKHFNISR ASVDQLPVPG PSITKPRPAR KPSLDHPPPP STDDDERWSS TAISLTLEDE
LAEDELNIGH PHPPETFVHD LSPSRPQDSL LVAEPPPKPD SRIPLPSHPA TRPIHQPAQK
TPHPPISARH ARARSRSQSV FSLSTPAATR SPNRASALRH QLDPHHTLQI ATPSPGPVLS
TSPLALSPAS PAAHPPPQQK TVSAAYTVPL NTDLLLLQST RKPGSRGRSL SDTFVRKTRS
FIGLLPPPTT PPRYSLHGPL QSFTITKPVP SALAKQAILK DLLASSSHLP QEQQQHHRPP
SDGDNELRKL FRNHNATDQA SACIASDTFQ ASAEDDDDEE DAFPLIDSPQ VTEMLGVKAD
FVIAVAGPKG VGKSTIISRA LRKSMDAGDA VELYRDACAN RISAVVANIG SASPGPGPLE
DPRSKLSQAP KVLQVLEIDQ PILADKCIST RRAKEGLLWP AGLPHLDGVL LCYDATDPHA
LDHLRPLLHS FWTRGGIALI VLACKSDKEE HRNATSPLKA AELVNVYGTG MIQLDGGTDD
PGKKMRNSFN WIVKAIKEAR GEHRSYSRAS STNILGSMYG DDEGRCSRSS SVVASMTTTL
GGDGPSSGPG AGTSEDDEEE ELAAGSADDG HDQPVPGNTA LPSPARTPRK NTPASLAQLD
TPGPSSAAAS RVLISASSSS PTLASDPLLH IDDADGDSFS NNALVAMSYE TSTRPDGSFM
HGGSTPGSPR EASHSGPVVA DTPGRSGASV AGEASPLLPT SPAASGSGPP PKDAPSPDAA
GPGNRALDPS KGLSGSGKHA VQKAIAMSQR GADMDLHFEK SVVIDKFVFA TVSGNEPSFV
DQFLIIFRRF ATPFEVLSAL IFRFDFVSTH IDRDPILGRY AHLKICHVLT SWLEIYPGDF
AQPATLTVLK AFNGLMISVT WLLHYAIETM PLIKMIGRMT DEDVGWALPD STEEGAVQGV
LECVKRLQLA LAVPASASSV TSRGSLVADS HHDEPSLPMT PLTTGKSVDY PRSEASPRLE
KFPSTFMSTD QLASTAASSP VHAFSPHDRH HLPPSSHTKP SSSSEEYNNV KHDALHHPLS
AIDSTENFIA ATLPLRSTLT ASSFQSDHKA ELKALHDASI LLLSIPEESI ALQITRLEWN
IFSQMKPRHL IRYVLAPRDP NNPRKALRDP NSPIAKSTDY LNYLAVWASS MILIQEKLKS
RARVLLKLMK VAYELRDMDD FHSLMGVLAG IEAQPVYRLD ATFEVVQHMD LQAYRRYLSL
KKLMSSQRSF SAYRLARQTA SSQCVPYLGT YLQDITAVNE VKDDMKDGKV NLTKMIQIAK
SASAVLNCNL LAPKIVFDPK ISNLIIKIPV LSEDAQYELS YKYKPRLQSS SHNSMLPGGN
NSSAGTGGSG GGIMSVLAAA AAATSAPGPS TAPPSSGALP MSAGPTADPT GHVGPLTSSA
SSGSLAPGPA SSAALFSAST ASEPAPFAPT PSASSSAIQS VAHVGAATSL VAKKGTRKLK
QLLSTAITHS SSSAHPAPQH ASSAH
//