ID A0A180H6D7_PUCT1 Unreviewed; 1705 AA.
AC A0A180H6D7;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=PTTG_01415 {ECO:0000313|EMBL:OAV99983.1};
OS Puccinia triticina (isolate 1-1 / race 1 (BBBD)) (Brown leaf rust fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=630390 {ECO:0000313|EMBL:OAV99983.1};
RN [1] {ECO:0000313|EMBL:OAV99983.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV99983.1};
RG The Broad Institute Genome Sequencing Platform;
RA Ward D., Feldgarden M., Earl A., Young S.K., Zeng Q., Koehrsen M.,
RA Alvarado L., Berlin A., Bochicchio J., Borenstein D., Chapman S.B.,
RA Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T., White J.,
RA Yandava C., Izard J., Baranova O.V., Blanton J.M., Tanner A.C.,
RA Dewhirst F.E., Haas B., Nusbaum C., Birren B.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OAV99983.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1-1 BBBD Race 1 {ECO:0000313|EMBL:OAV99983.1};
RA Cuomo C.A., Bakkeren G., Szabo L., Khalil H., Joly D., Goldberg J.,
RA Young S., Zeng Q., Fellers J.;
RT "Comparative analysis highlights variable genome content of wheat rusts and
RT divergence of the mating loci.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OAV99983.1}.
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DR EMBL; ADAS02000001; OAV99983.1; -; Genomic_DNA.
DR STRING; 630390.A0A180H6D7; -.
DR VEuPathDB; FungiDB:PTTG_01415; -.
DR OrthoDB; 5474327at2759; -.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 2.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 336..359
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
FT COILED 1606..1636
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1705 AA; 192383 MW; 66015766E93F68F0 CRC64;
MAEQRPISFC EHVQLTALGV QPASIGFNTL TMESERYVCV REEVNSAKQV IIIDLADANN
VMRRPISAES AIMHPVQKVI ALRAQRQLQV FNIELKQKVK SHAMNEDVSF WKWINDSTLG
IVTETAVYHW AALDPTSPPV KVFDRNANLA GHQIINYRAS PDEKWMVLVG ITGNPSNPSA
FKVKGSMQLY NKDRAVSQSI EGHAASFADY RLEGATTDSK LFAFAVRTAA GAKLHIVEID
HQAGQPVFAK KAVDVFFPPE ATNDFPVAMQ VSKKHKIIYM VTKYGFIHLY DVETAACIYM
NRISGETIFV TAEHETSSGI IGVNRKGQVL SVTVDEETIV PFILNTLKNP ELAIKLASRA
DLPGADDIYV QQFQQLFSSG QFSEAAKVAA NSPRGILRTP QTIEQFKAVP MQPGQLSPIL
QYFGILLERG KLNQHESLEL ARPVLVQGRK QLLEKWLKED KLDCSEELGD IVRAHDMTLA
LSVYLRANIP NKVCACFAET GQSSKIVVYA KRVGFTPDYA SLLQHITRLS PDSGAEFASS
LINDESGPLV DVERVIDIFM AQNMIQQATS FLLDALKENK PEQGYLQTKL LEMNLLNAPQ
VADAILGNEM FSHYDRPSVA NLCEKAGLLQ RALEHYEDIS DIKRVLVHTN LLNTDWLVNY
FGKLTVDQTV DCFCEMLKVN IRQNLQIVVQ AATKYSDLVG SVRLIEMFES FKTFEGLYYY
LGSIVNLSTD PEVHFKYIQA ATRTGQIREV ERICRESNYY PPEKVKNFLK EAKLSDQLPL
IIVCDRFDFV HDLVLFLYQN GLTSFIEVYV QKVNSQRAPQ VIGGLLDVDA DEMMIKNLLA
SVTGPIPVDE LVEEVEKRNR LKLILPWLEA RIAMGITDVG LYNAMAKILI DSNQNPEAFL
KENTIYDPLT IGKYCEKRDP TLAYIAYARG FCDEDLIRIT NENSMFKLQA RYLVKRRQLE
LWAQVLQPDN MHRRQLVDQV VSTAVPESQN PEDVSVTVKA FLAADLPIEL IELLEKIVLE
PSPFSDNANL KKLLLLTAIR SEKGKVMGYI DKLEDIDVSE IAGIAIEHGL FEEAFTLFRK
HKMHLEAMNV LVEHVVSIDR AAQYATKVNE PAVWSRLGKA QLDGLRIKDA IDSYIKADDP
TNYLELIETA DRAGKHDDMV RYLQMARKTL REPKIDTELC VAYAKTDRLH DMEEFLSMSN
VADQLSAGEQ VFEAGLYEAA RLLFSAISNW ARLATTLIYL GDNQAAVDCA RKAGNTQVWK
QVNSACIDKK EFRLAQVCGL NLVVHAEELQ SLVKLYENRG YFEELMQLLE AGLGLERAHM
GMFTELSILY AKHKPAKLME HLKLFWSRIN IPKVIRATEQ AHLWPELVFL YIHYDEFDNA
VLAMMERSAD AWDHGQFKDI VVKVANVELY YKALSFYLQE QPTLLTDLLT VLVPRIDHTR
VVKIFQKTDN LPLIKPYLIA VQHLDLPAIN EAYHDLLIEE EDYATLRDSL SNHDNFDQVS
LAKRLENHEL LEFRRLAALL YAKNGKFEES IGLSKDDKLF KDAMITAASS ASNEIVEELL
EYFVKIGNKE CFAACLYICY DLIRPDVVED LQWRHALNDY TMPYRLQQMR EQTSRLEQIE
RQLKELSLRS AKAVEETESQ PIIGPGFGGR LMLTQGPSNG MMVGQPTGAY GGGPPSAGGM
MRGMQAQPTG MMGQQFTGMP GMMGF
//
