ID   A0A183AHN8_9TREM        Unreviewed;       763 AA.
AC   A0A183AHN8;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0000313|WBParaSite:ECPE_0000648601-mRNA-1};
GN   ORFNames=ECPE_LOCUS6473 {ECO:0000313|EMBL:VDP78453.1};
OS   Echinostoma caproni.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Plagiorchiida; Echinostomata; Echinostomatoidea; Echinostomatidae;
OC   Echinostoma.
OX   NCBI_TaxID=27848 {ECO:0000313|Proteomes:UP000050740, ECO:0000313|WBParaSite:ECPE_0000648601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:ECPE_0000648601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP78453.1, ECO:0000313|Proteomes:UP000272942}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Egypt {ECO:0000313|EMBL:VDP78453.1,
RC   ECO:0000313|Proteomes:UP000272942};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; UZAN01043473; VDP78453.1; -; Genomic_DNA.
DR   WBParaSite; ECPE_0000648601-mRNA-1; ECPE_0000648601-mRNA-1; ECPE_0000648601.
DR   Proteomes; UP000050740; Unplaced.
DR   Proteomes; UP000272942; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45638:SF4; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 2.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272942};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   DOMAIN          94..133
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          146..239
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   REGION          308..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          731..763
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        311..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   763 AA;  85411 MW;  44579251954E5D54 CRC64;
     MISFCPFFCF PLIYIPCFVF NKRPPSGRLD RVKNYLSMRR VPYPLTEKVI DWFDYLWYTN
     KITDEENVLT SLPDKLKAEI AIQMHLDTLK RVEIFQNTEE GFLSELVLRL RMVLFAPGDY
     VCRKGKITLV LYVGTDRMKL KKTGKINIGE IGKQMFIVNR GTLHVLGDDG HTVLATLRAG
     SYFGELSILN LGRYGNRRTA SVRSLGYSDL FRLSKSDLWD VLKEYPAARR KLESHAYKKI
     SDYKVCVPNK VRGSAFQQTM SNGDDGLFCS LAGNRIDSSV NSRILGPGNY FSRHGRSYTC
     GAIHSSGDGS DGYGSDPSRL STSFFSPQQS PTPPVSQIPD SVCSLQENWS ESSSHPIRPD
     RQVNATRCFQ KNLNSLPETL PFETHGYSPK QVGEFHTSYP SYISRATSSN TNCNLPFPVI
     SAQPRERGIS IHDADQRGPQ CRKDALSGDS ALPRMRNFSV PADLVNRVTM VPLLECSPAN
     VMNEQAYCHM GPEGETFMSY ISPGDENIFL IDDSPQQHLS TVRFNLNDYE DPKSGKDLSE
     YDCLKLAEEM NRGMEWSRPN TGNVPSICLE GASNSSSSCS PSLGPKTSVH SVPPSFCPLQ
     PAERPTDFGW ETTHLLNVPQ LRPSTSASTR PPWPRVCQPF SIVSSVCPNS HQSSPSCFTP
     TTRNCELVKE FTRLRQKIYM LEYENALLHR HTRRTSLEST ACCGLNMPSN ATGPVKMADT
     RVTVKRSTSL QVPMNERRMK VRGPPKQPAV TPRSDLDPSN TSI
//