ID A0A183E220_9BILA Unreviewed; 770 AA.
AC A0A183E220;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protein kinase domain-containing protein {ECO:0000313|WBParaSite:GPUH_0001503101-mRNA-1};
GN ORFNames=GPUH_LOCUS15011 {ECO:0000313|EMBL:VDN25195.1};
OS Gongylonema pulchrum.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Spiruroidea; Gongylonematidae; Gongylonema.
OX NCBI_TaxID=637853 {ECO:0000313|Proteomes:UP000050760, ECO:0000313|WBParaSite:GPUH_0001503101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:GPUH_0001503101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDN25195.1, ECO:0000313|Proteomes:UP000271098}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the XPC family. {ECO:0000256|ARBA:ARBA00009525}.
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DR EMBL; UYRT01081930; VDN25195.1; -; Genomic_DNA.
DR WBParaSite; GPUH_0001503101-mRNA-1; GPUH_0001503101-mRNA-1; GPUH_0001503101.
DR Proteomes; UP000050760; Unplaced.
DR Proteomes; UP000271098; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR Gene3D; 2.20.20.110; Rad4, beta-hairpin domain BHD1; 1.
DR Gene3D; 3.30.70.2460; Rad4, beta-hairpin domain BHD3; 1.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 2.
DR InterPro; IPR018327; BHD_2.
DR InterPro; IPR004583; DNA_repair_Rad4.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR018325; Rad4/PNGase_transGLS-fold.
DR InterPro; IPR018326; Rad4_beta-hairpin_dom1.
DR InterPro; IPR018328; Rad4_beta-hairpin_dom3.
DR InterPro; IPR042488; Rad4_BHD3_sf.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR PANTHER; PTHR12135:SF0; DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS; 1.
DR PANTHER; PTHR12135; DNA REPAIR PROTEIN XP-C / RAD4; 1.
DR Pfam; PF10403; BHD_1; 1.
DR Pfam; PF10404; BHD_2; 1.
DR Pfam; PF10405; BHD_3; 1.
DR Pfam; PF03835; Rad4; 2.
DR SMART; SM01030; BHD_1; 1.
DR SMART; SM01031; BHD_2; 1.
DR SMART; SM01032; BHD_3; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000271098};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 669..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 451..503
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01030"
FT DOMAIN 505..560
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01031"
FT DOMAIN 567..653
FT /note="Rad4 beta-hairpin"
FT /evidence="ECO:0000259|SMART:SM01032"
FT REGION 207..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 770 AA; 89139 MW; 474C7C7D0FFAACA9 CRC64;
MEELEMLDEM SYKPPPQDSV EITIKAPKPV ETIEAKWAKF IRQAMHLLCY IAHLQIWTRA
LVRNEALMSL CLSLIPEGYI TAAQHGLEVA TAERFLKWFR SAFQQAQKDY IAKDGFCDAQ
VERLEELIGD RVYENDKDLA SLLFLCMLAM KQSTRLCLSC QPVTHRLTMQ MLQSVHTEKF
VKESIDNRDA EWEDKLEEVT KKVEVKEQNA VSATEETAVE DSKDKKARKS RKNSKSEAKE
SASTSDVGKK LRIERNYWVE YWDDNDGMDP WTSTVDMPAK VEADATAPMH YVIVIDNGFG
MRDVTARYAS KFLASDMRRL RADPDWWAQT IKLFRSKDRR RERMEDVAIH EYLMSQPTPA
TVAEYKNHPF TVDMPAKVEA DATAPMHYVI VIDNGFGMRD VTARYASKFL ASDMRRLRAD
PDWWAQTIKL FRSKDRRRER MEDVAIHEYL MSQPTPATVA EYKNHPLYVL KKDILKYEAI
YPENQQPIGQ IRGIDIYPRS SVFHLDGSLN WMKQARMVKA GEKPYKIVKG RVNPRIPPEL
REPRSLELFG FWQTEPYVPP KVVDGRVPRN EFGNLYVYKS SMIPEGCVHV RLDGLVAGCV
HVRLDGLVTV ARQLDIDCVP AVVGWEFHKG GNHPIIEGCV VLKEHEKALR AAWREFYERK
QVAAEKVTFW NILFSFFLIH YVTASVLHLK TTRIYGARFQ RRKERAIKNW RRLVKGLLTL
KKLVDEKLEH ETAVEVKAEE TPATDDMAFS WPRTAFNLSG TSTEKHQHRL
//
