ID A0A183H5D1_9BILA Unreviewed; 562 AA.
AC A0A183H5D1;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=OFLC_LOCUS2691 {ECO:0000313|EMBL:VDO33881.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000269001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0000269001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO33881.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; UZAJ01001602; VDO33881.1; -; Genomic_DNA.
DR STRING; 387005.A0A183H5D1; -.
DR WBParaSite; OFLC_0000269001-mRNA-1; OFLC_0000269001-mRNA-1; OFLC_0000269001.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd09931; SH2_C-SH2_SHP_like; 1.
DR CDD; cd10340; SH2_N-SH2_SHP_like; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46257; TYROSINE-PROTEIN PHOSPHATASE CORKSCREW; 1.
DR PANTHER; PTHR46257:SF3; TYROSINE-PROTEIN PHOSPHATASE CORKSCREW; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 30..126
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 146..243
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 270..547
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 460..538
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 562 AA; 64148 MW; D7BBA146A7550CFB CRC64;
MSGEHNVDRT FQDFDCVVNG GGSMSLQPSN FYYPISGVEA ERLLNTYGSE GSFLARPSGS
SPSNYTLSVH KGDRIKHVKI QNNGDCLDLY GGETFASLSE LVQFYVENPG QLRERDGEII
VLKCPLVIPP TEAIGWAFSR PSTERWFHAG LSGPEAERLL LTEGKHGTYL VRESHSSPGQ
FAISVKAADD KVIHVMIYNK NDKFDIGGGA TFSAISELLE HYKRNPMVDQ AGTVVNLKQL
LPSTRLPATG IDTRYYRLEQ VNRTTGKDGF ADEFEKLQHQ EPTQFVSRRE GKKISNVCKN
RYKNIIPYDH TRIVLNVSDA DSSDYINANH IEILGDEYQE FAGLRRNYIS TQGCLPNTID
DFWNMVWQQN SRIIVMTTKE VERGRIKCCR YWPLKNETEK FGKNGELVIK SVEEVENTDY
TMRLLQFMNT NHDNETRLIW HFQFLGWPDH GCPTDPRTVL YFLEKVNECE EHNCDENAGP
IIVHCSAGIG RTGTFIVIDI LLNQIKRLGP HCQIDIPRTV QMIREQRSGM VQTEQQYRFV
YQAVSYYMAI INRRLDSEVS YM
//
