ID   A0A183HF53_9BILA        Unreviewed;       357 AA.
AC   A0A183HF53;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=NAD(+) ADP-ribosyltransferase {ECO:0000256|ARBA:ARBA00012020};
DE            EC=2.4.2.30 {ECO:0000256|ARBA:ARBA00012020};
OS   Onchocerca flexuosa.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0000611401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:OFLC_0000611401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=NAD(+) + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D-
CC         ribosyl)n+1-acceptor + H(+).; EC=2.4.2.30;
CC         Evidence={ECO:0000256|ARBA:ARBA00033987};
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DR   AlphaFoldDB; A0A183HF53; -.
DR   STRING; 387005.A0A183HF53; -.
DR   WBParaSite; OFLC_0000611401-mRNA-1; OFLC_0000611401-mRNA-1; OFLC_0000611401.
DR   Proteomes; UP000050787; Unplaced.
DR   GO; GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:InterPro.
DR   CDD; cd08003; WGR_PARP2_like; 1.
DR   Gene3D; 1.20.142.10; Poly(ADP-ribose) polymerase, regulatory domain; 1.
DR   InterPro; IPR004102; Poly(ADP-ribose)pol_reg_dom.
DR   InterPro; IPR036616; Poly(ADP-ribose)pol_reg_dom_sf.
DR   InterPro; IPR036930; WGR_dom_sf.
DR   InterPro; IPR008893; WGR_domain.
DR   PANTHER; PTHR10459; DNA LIGASE; 1.
DR   PANTHER; PTHR10459:SF60; POLY [ADP-RIBOSE] POLYMERASE 2; 1.
DR   Pfam; PF02877; PARP_reg; 1.
DR   Pfam; PF05406; WGR; 1.
DR   SMART; SM00773; WGR; 1.
DR   SUPFAM; SSF47587; Domain of poly(ADP-ribose) polymerase; 1.
DR   SUPFAM; SSF142921; WGR domain-like; 1.
DR   PROSITE; PS51060; PARP_ALPHA_HD; 1.
DR   PROSITE; PS51977; WGR; 1.
PE   4: Predicted;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          70..167
FT                   /note="WGR"
FT                   /evidence="ECO:0000259|PROSITE:PS51977"
FT   DOMAIN          194..311
FT                   /note="PARP alpha-helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51060"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   357 AA;  41053 MW;  D3A7C2D2914397CD CRC64;
     LQTKKKEDSK IDISGNDDND EEEINKPERT SNSESQKSND SDSITNKDMK KVILKGIAAV
     DPECRELIDT AHVYTESGDV YDALLNQTSA QHNNNKYFIM QLLESDGSKQ YWVWFHWGRV
     GYKGQTSLNS CETDLMLAKK LFCDKFLDKT KNRWAERTNF EKVAGKYDYL PTDYSKIIEE
     KKNDNDIDDK KEVESKLDPD LQHLLTLICN IRAMEETMTE LEYDATKAPL GKVTDEQIKA
     GYAALGKIEQ HIKKKDFSSS FVEAVNNYYT KIPHFFGMRQ PPMIKTIKQL KTEIKLLEAL
     SEIGVAIRTF KKKGDVNIHP IDRHYMNMKC EISIVCADDP KYKNGFSIDI ENGPQEE
//