ID A0A183I1Q3_9BILA Unreviewed; 1052 AA.
AC A0A183I1Q3;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=DNA helicase {ECO:0000313|WBParaSite:OFLC_0001366601-mRNA-1};
GN ORFNames=OFLC_LOCUS13665 {ECO:0000313|EMBL:VDP14337.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001366601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0001366601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP14337.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; UZAJ01040323; VDP14337.1; -; Genomic_DNA.
DR STRING; 387005.A0A183I1Q3; -.
DR WBParaSite; OFLC_0001366601-mRNA-1; OFLC_0001366601-mRNA-1; OFLC_0001366601.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 6.10.140.1440; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 2.
DR InterPro; IPR040793; CDH1_2_SANT_HL1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623:SF14; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF18375; CDH1_2_SANT_HL1; 1.
DR Pfam; PF00385; Chromo; 2.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00298; CHROMO; 2.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00598; CHROMO_1; 2.
DR PROSITE; PS50013; CHROMO_2; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..61
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 86..151
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 194..334
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 462..613
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 741..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1052 AA; 122546 MW; 088CA9867B7B6538 CRC64;
MLPENGSEME LERQYLIKWL GWSHLHNTWE SENSLKLCNA KGLKKIDNYM KRLRDIEEWK
LTADKEYIEF FDCEQQMNDE LNEQYKIIER VIAHQISRNQ GETEGTEYFV KWCGLPYSEC
TWEEEHLIAR QFKDKIDAYF DRRDNGKIPN KHCPALRKRP RFEKLNDIPD FLQRKDDPEH
ELRDYQLEGV NWMLHAWTKE NSCILADEMG LGKTIQSISF LSVLYHKYQL YGTFLVVVPL
STMASWQHEF ETWAPDLNVV TYVGDVTSRD LSFLGSFEWT VLAVDEAHRL KNDESLLYRS
LFEFTTNHRL LITGTPLQNS LKELWALLHF IMPEKFDSWP EFEAEHHDSD HKTIASLHRK
LQPFLLRRVK KDVEKSLPAK VEQILRVDMT AQQKQYYKWI LTKNYKELSK GVKGSINGFV
NLVMELKKCC NHASLVRSYD QSEEGADARL QQLLKSSGKL ILLDKLLCRL QETGHRVLIF
SQMVMMLDIM QEYLQLRRFP SQRLDGSMRS DLRKAALDHF NAQNSPDFCF LLSTRAGGLG
INLATADTVI IFDSDWNPQN DLQAMSRAHR IGQKKQVNIY RLVTKASVEE EIVERAKRKL
VLDHLIIQRM DTTGRTVLSK TNVANGTMPF DKQDLTMILK FGAEELFKEK EGEEQEPEVD
IDNILQGAET RECDQQNCGS ELLNAFRYAD FSFDENKDVP TLTVTTVQLE TDQKDLATSK
SWDEIIPEVD RKKFADEERE RAEKELFLGP RQRTKIPEVA AEAGDSDEDE KKKKGRKRGR
DSPLSEEECS DDDKPKRARK KLLFNFTESE IRKFIRSFRK FAEPLTRLEA IAQDAELEEF
SKSELEQLGN ELLIGCQKAQ NEYEGKIKEA MKKPMEGGKR RQDRGAIFKF GNIDVYVRPL
LKMQSDLLPL HNLVKNAGDI RLLQIPGYPK KQKGWDVEWD IADDLALLKG IYQYGLGSWE
EIKMDPDYGL AEKIWLKDKS KKPQSKHIQA RAEYLLKYLA RNTMAEEGTP MKVKSSKKNH
SVSSTSGALV RNFLLNRILY DRQFNQIIKF IR
//
