ID A0A183I2F4_9BILA Unreviewed; 490 AA.
AC A0A183I2F4;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=FYVE zinc finger {ECO:0000313|WBParaSite:OFLC_0001391701-mRNA-1};
GN ORFNames=OFLC_LOCUS13916 {ECO:0000313|EMBL:VDP14994.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001391701-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0001391701-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP14994.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; UZAJ01040466; VDP14994.1; -; Genomic_DNA.
DR STRING; 387005.A0A183I2F4; -.
DR WBParaSite; OFLC_0001391701-mRNA-1; OFLC_0001391701-mRNA-1; OFLC_0001391701.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF267; GUANYL NUCLEOTIDE EXCHANGE FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13320)-RELATED; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 163..264
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 340..390
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 245..272
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 490 AA; 56550 MW; A6A9CF2612152A01 CRC64;
MVKEAHKFLL EKISSKIENW DSRDPNMAEC LKNGAGLLKC CLPYLKEKKK HVDDFIRLLQ
DNEELAHATV KFEEQVMGKI SIIQQLDIVH QNVVRYTILL EAYKKHLIPE SNEFEVCKEA
LVQLSKVSEL VDRQISRAEL EKRLIDLYRR LEGRFNVFEA NRHLLFEGEL MKQSRKDLQP
RYLILFSDVL LICKYSRTPS LGTDANFHSE FYKFLVSRIR VKAEEHGEYE THFQLYTTQK
SAVFIAKTKR ERDDWVKRIN EAKMEAKELR RIKIARNKVF NVRVIHKNEP AGKSTSDAKM
SNNGSDHNVS LNNMPISGKH KYTPLWIPDP KATSCMMAGC STKFNVLNRR HHCRECGYLI
CRSCVGYAPV KTNSYYMRSK VCPECYVKIT KKWKGELGST IFTAPENESL TKTSVPSRNA
EGVVSGTVFL RNQKGGENEK WGRLTSHADG VLVLCFYNAE FFQAVTSEGL KHSKGKYRTK
LNSWVCKGQI
//
