ID A0A183I3H6_9BILA Unreviewed; 590 AA.
AC A0A183I3H6;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=glutamine--fructose-6-phosphate transaminase (isomerizing) {ECO:0000256|ARBA:ARBA00012916};
DE EC=2.6.1.16 {ECO:0000256|ARBA:ARBA00012916};
GN ORFNames=OFLC_LOCUS14288 {ECO:0000313|EMBL:VDP16347.1};
OS Onchocerca flexuosa.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX NCBI_TaxID=387005 {ECO:0000313|Proteomes:UP000050787, ECO:0000313|WBParaSite:OFLC_0001429601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:OFLC_0001429601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP16347.1, ECO:0000313|Proteomes:UP000267606}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-
CC phosphate + L-glutamate; Xref=Rhea:RHEA:13237, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359, ChEBI:CHEBI:58725, ChEBI:CHEBI:61527; EC=2.6.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001031};
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DR EMBL; UZAJ01040740; VDP16347.1; -; Genomic_DNA.
DR STRING; 387005.A0A183I3H6; -.
DR WBParaSite; OFLC_0001429601-mRNA-1; OFLC_0001429601-mRNA-1; OFLC_0001429601.
DR Proteomes; UP000050787; Unplaced.
DR Proteomes; UP000267606; Unassembled WGS sequence.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:UniProtKB-EC.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00714; GFAT; 1.
DR CDD; cd05008; SIS_GlmS_GlmD_1; 1.
DR Gene3D; 3.60.20.10; Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1; 1.
DR InterPro; IPR017932; GATase_2_dom.
DR InterPro; IPR047084; GFAT_N.
DR InterPro; IPR035466; GlmS/AgaS_SIS.
DR InterPro; IPR029055; Ntn_hydrolases_N.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR PANTHER; PTHR10937; GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING; 1.
DR PANTHER; PTHR10937:SF0; GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING); 1.
DR Pfam; PF13522; GATase_6; 1.
DR Pfam; PF01380; SIS; 1.
DR SUPFAM; SSF56235; N-terminal nucleophile aminohydrolases (Ntn hydrolases); 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51278; GATASE_TYPE_2; 1.
DR PROSITE; PS51464; SIS; 1.
PE 4: Predicted;
KW Aminotransferase {ECO:0000256|ARBA:ARBA00022576};
KW Glutamine amidotransferase {ECO:0000256|ARBA:ARBA00022962};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2..306
FT /note="Glutamine amidotransferase type-2"
FT /evidence="ECO:0000259|PROSITE:PS51278"
FT DOMAIN 377..528
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 590 AA; 66521 MW; 8C9CE6DBF9D14C8B CRC64;
MCGIFAYLNF LTPRKRSEII DILLRGLHRM EYRGYDSAGL AVDDEADNTK IGSKVALLKK
VGKVSVLEDY IKESHIRSDN IVYKTHCGIA HTRWATHGSP RDVNSHPQRS NTQNEFLVVH
NGIITNYREV KEYLMKKGYE FESETDTEVI VKLIQHITNK CEGASFRQLV EATIQHLEGA
FALAFKSNRF PGQLVATRRG SPLLIGIKTT GRLSTNHFPV FFSKARRFIS SEYANESYME
PTMVIETGFK TSTPIKGGEA SNEAAFQIFD YKEAEYFVAS DASAVVEHTK QVIFLEDDDV
AMIENGSLSI HRIKRGDEIP QTREVQNLTL ELQEIMMGNF KTFMQKEIYE QPDSIVNTMR
GRILDNGTVV LGGIKDYLLD IKRCRRLILV ACGSSYHSAL ACRQIMEELT ELPVVLELAS
DFLDRETPIF RDDVCFFISQ SGETADTLNA LRLVLRLISK MVFKYCKPRG ALTIGITNTV
GSSICRETHC GVHINAGPEV GVASTKAYTS QILSLVMFAL TMSDDRISMR KRRNDIVNGL
QQLPDLIREV LKLDDEVLTI AKKIYKERSL LIMGRGYNFA TCLEGALKIK
//
