ID A0A183JZ47_9TREM Unreviewed; 1097 AA.
AC A0A183JZ47;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=DNA mismatch repair protein {ECO:0000256|PIRNR:PIRNR037677};
GN ORFNames=SCUD_LOCUS8004 {ECO:0000313|EMBL:VDP28831.1};
OS Schistosoma curassoni.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6186 {ECO:0000313|Proteomes:UP000050789, ECO:0000313|WBParaSite:SCUD_0000800401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SCUD_0000800401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP28831.1, ECO:0000313|Proteomes:UP000279833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dakar {ECO:0000313|EMBL:VDP28831.1}, and Dakar, Senegal
RC {ECO:0000313|Proteomes:UP000279833};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|PIRNR:PIRNR037677}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|PIRNR:PIRNR037677}.
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DR EMBL; UZAK01032564; VDP28831.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183JZ47; -.
DR STRING; 6186.A0A183JZ47; -.
DR WBParaSite; SCUD_0000800401-mRNA-1; SCUD_0000800401-mRNA-1; SCUD_0000800401.
DR Proteomes; UP000050789; Unplaced.
DR Proteomes; UP000279833; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR037677};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PIRNR:PIRNR037677};
KW DNA repair {ECO:0000256|PIRNR:PIRNR037677};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037677};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR037677};
KW Reference proteome {ECO:0000313|Proteomes:UP000279833}.
FT DOMAIN 971..987
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 123328 MW; E8C3B98EEB83AEC6 CRC64;
MSSPTTSSVS KRRRVIIESS DDEDEAPALT KEKAEAVNKH DLQLSKYSFS PQPVRQNGKK
INEAADESSL EMSVVTQVNE AFEDETVSWT HLSLPFLEPS KIKDINGRRP DHPEYDSHTL
YVPEEFKTKQ TPGMRQWWEL KSRYTDVILF FKVGKFYEMY HMDAMIGVKE LGLVFMKGNF
AHCGFPEVAF PRMADQLVRK GYKIARIEQT ESIDAMNERC KRKSSSEKVV RREVCQLITP
GTCTASTRSE ISDVKAVETG DVENDDESFR DLINLANPDS FLLAVVESHG NKSYPFAFGI
GLLNASTGKI NIGQFLDDRH CSRLRTFLSH HPPNQLLIER GTAGVAIKSL IKTSLSCVPT
EFLTPTKQFW SAKNTVQELE TADYFPKRMS NITVDSNHVS KVSSFPDKES WPDVLLNMLS
EDDPLGRTVK SEWELAFRCL GALIYYLRYC LIDREVLSLG FIDVYVPIDM KNTNSQRSPG
SIELFYDTQS QMVLDSITLS NLDIIRNNVD GSQEGSLLQR LNTCCTFFGR RLLRQWITAP
PCNPNVIRQR QLAIENLISI SDIIPKLRDK LAQLPDLERL ITKIHLLGSK GDKNHPDSRA
IIFEEVQYSR KNITDFVATL DGFELSYKIM HEINHYSLSS AYLKKLVTLT SLSGNFPDIS
EKINYFKNAF DAEKAKNEGR IIPEPGIDPE YDESVSEIKR IVEDMDRFLL KWSKTFGTRL
AYWGTGRNRY QIEIPESLAS RVPNSWQLSS QRKGVKRYTC SETQQWLSEL TAAEERKDAS
LRSIMQHIFS SFSESFTEWH MAMSCLAELD CLIALSSYST NASDVMCLPE FIDLNSSTKP
LLEIVDGIHP CLINTFSGGD IIPNDIKLGT TSSMIYSPTH HTLRDTFNNV SVILVTGPNM
GGKSTLMRQA ALLVILAHLG CRIPAKSCKL TPVDRIFSRL GASDRMLSGE STFLVELSET
ASILHHITPH SLVLMDELGR GTSTHDGSAL AGAVVSYLAK PNGRFFDGCG PRTLFSTHYH
SLVDQVANTD PSTSDEDMNH LCIGLGHMSC MVEAESESTN DLENITFLYK FIPGACPKSY
GFNAARLAML PDKVRVS
//
