ID A0A183L3A5_9TREM Unreviewed; 338 AA.
AC A0A183L3A5;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=DH domain-containing protein {ECO:0000313|WBParaSite:SCUD_0002181601-mRNA-1};
GN ORFNames=SCUD_LOCUS21813 {ECO:0000313|EMBL:VDP76660.1};
OS Schistosoma curassoni.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=6186 {ECO:0000313|Proteomes:UP000050789, ECO:0000313|WBParaSite:SCUD_0002181601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SCUD_0002181601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP76660.1, ECO:0000313|Proteomes:UP000279833}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dakar {ECO:0000313|EMBL:VDP76660.1}, and Dakar, Senegal
RC {ECO:0000313|Proteomes:UP000279833};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UZAK01047532; VDP76660.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A183L3A5; -.
DR STRING; 6186.A0A183L3A5; -.
DR WBParaSite; SCUD_0002181601-mRNA-1; SCUD_0002181601-mRNA-1; SCUD_0002181601.
DR Proteomes; UP000050789; Unplaced.
DR Proteomes; UP000279833; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR PANTHER; PTHR22826:SF106; TRIO, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000279833};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 304..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 94..297
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 34..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 127..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 127..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 338 AA; 38725 MW; CF00CAE7EB4CF0D7 CRC64;
MSTNELGPQS VVGLKDISLD MMVMQANTMK LSDQEASRSN YSKDEPCSIH DSFSIDRHSS
DENSPGAKMK EDQCAEEMTI SGSAGDDVSR ALIQRRQPLM ELVSSEEGYV RRLKLVKDFY
IPAVNPPTTA QSNTENIGAP SSLPHSDSHA SPPVAPEDLA ARWRIIWGNW IQLYEWHSAF
LEKLVSVVES DPDRIPKLFI DSRARLRSIY SKYCENHRKA ALIAEQYRDF FEELRIFIGD
KEDVVSHLMQ PVQRIMRYQL PIAEILKYTQ RACSPDLLLW KKTLEIMKEI PKDTQLILEV
SFELYIVFYI VVICLLASFQ CHINIFMCFL PSSRKNLI
//
