ID A0A183LLV9_9TREM Unreviewed; 436 AA.
AC A0A183LLV9;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=fumarate hydratase {ECO:0000256|ARBA:ARBA00012921};
DE EC=4.2.1.2 {ECO:0000256|ARBA:ARBA00012921};
GN ORFNames=SMRZ_LOCUS4784 {ECO:0000313|EMBL:VDO63183.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000478501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0000478501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO63183.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDO63183.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate
CC from fumarate: step 1/1. {ECO:0000256|ARBA:ARBA00004859}.
CC -!- SIMILARITY: Belongs to the class-II fumarase/aspartase family. Fumarase
CC subfamily. {ECO:0000256|ARBA:ARBA00009084}.
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DR EMBL; UZAI01001558; VDO63183.1; -; Genomic_DNA.
DR STRING; 48269.A0A183LLV9; -.
DR WBParaSite; SMRZ_0000478501-mRNA-1; SMRZ_0000478501-mRNA-1; SMRZ_0000478501.
DR UniPathway; UPA00223; UER01007.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0045239; C:tricarboxylic acid cycle enzyme complex; IEA:InterPro.
DR GO; GO:0004333; F:fumarate hydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006106; P:fumarate metabolic process; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR InterPro; IPR005677; Fum_hydII.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR018951; Fumarase_C_C.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR11444; ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE; 1.
DR PANTHER; PTHR11444:SF1; FUMARATE HYDRATASE, MITOCHONDRIAL; 1.
DR Pfam; PF10415; FumaraseC_C; 1.
DR Pfam; PF00206; Lyase_1; 2.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; L-aspartase-like; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000277204}.
FT DOMAIN 17..145
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 175..312
FT /note="Fumarate lyase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00206"
FT DOMAIN 378..429
FT /note="Fumarase C C-terminal"
FT /evidence="ECO:0000259|Pfam:PF10415"
SQ SEQUENCE 436 AA; 48042 MW; 2F5E879B22A977F4 CRC64;
MIGTDSQRLR VVEDSLGSIK VPLERYYGAQ TARSLENFNV CTRSDTMPVI YSLAMIKEVA
ACTNFKFGRI SSEISDAIVK ACREVYHGQH DNEFPLVIWQ TGSGTQTNMN VNEVLSSRAS
ELIEGSRSSK LTVHPNDHVN LGQVRSPLSL LQWKLYGRCM NLWMLSKLEG PICNVGQELS
GYVSQLQQAV DSIKSQLPLI CYLAVGGTAV GTGLNCFKGF DEELYLVFKP AENKFAALAG
HDALLQLSGC FNTTATALMR LSNDFCLLSS GPNCGLSEFV LPANEPGSSI MPGKVNPTQC
ESLRMVCLQI MGNHFTTSMA ASQGQLELNV YKPLIAANLL HTCDLLTDST RCFADKCVKG
LQLNREKIQE YVDKSLMLVT VLTPHIGYDL SAKLVYHASK FKKGLRESAI ELNLLCGEKF
DEIVKPMEMA FPHNNK
//
