ID A0A183LP86_9TREM Unreviewed; 385 AA.
AC A0A183LP86;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=TGF_BETA_2 domain-containing protein {ECO:0000313|WBParaSite:SMRZ_0000561201-mRNA-1};
GN ORFNames=SMRZ_LOCUS5611 {ECO:0000313|EMBL:VDO66973.1};
OS Schistosoma margrebowiei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=48269 {ECO:0000313|WBParaSite:SMRZ_0000561201-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMRZ_0000561201-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDO66973.1, ECO:0000313|Proteomes:UP000277204}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Zambia {ECO:0000313|EMBL:VDO66973.1,
RC ECO:0000313|Proteomes:UP000277204};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UZAI01001961; VDO66973.1; -; Genomic_DNA.
DR STRING; 48269.A0A183LP86; -.
DR WBParaSite; SMRZ_0000561201-mRNA-1; SMRZ_0000561201-mRNA-1; SMRZ_0000561201.
DR Proteomes; UP000277204; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF263; PROTEIN DECAPENTAPLEGIC; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000277204};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 265..385
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 164..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 44454 MW; 234A2E19FC1C4FB2 CRC64;
MRTSTSEGKH GIQWTAQNQL DDLDFADDLA LLPRTHEQMQ MKTASIAAVS ASIGFNIHKE
KTKVLKYNTD NTNPITLDGE TLEDVESFTY LESIIDEHGG SDADVKARIV KARAASLQLK
NIWNSKQLST NIKGINVLSL NNRASNKKIA KRYKRLQRIL NAQLKQQQQQ QKSETNQQSV
QRNKQNYIKQ RSRRLAQYQR RHNRASQDRY YYSDLDSTNE IVEDHDINED VSSHRKITHN
SYENNRENHH SQQQQQHQQY RYDITKSYSN VLQTNNHHYL DTTCQRRELI INFDAVGWAG
WVIAPQAYNA RYCLGQCPFP LSTHYNTTNH AVLLQLVHLL DVARISGPCC VPHQLSSQSL
LYHSQNGDVV LRVYEDMVVE SCACR
//
