ID A0A183P145_9TREM Unreviewed; 577 AA.
AC A0A183P145;
DT 07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT 07-SEP-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:VDP42840.1, ECO:0000313|WBParaSite:SMTD_0000808001-mRNA-1};
GN ORFNames=SMTD_LOCUS8081 {ECO:0000313|EMBL:VDP42840.1};
OS Schistosoma mattheei.
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX NCBI_TaxID=31246 {ECO:0000313|WBParaSite:SMTD_0000808001-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:SMTD_0000808001-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (JUN-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDP42840.1, ECO:0000313|Proteomes:UP000269396}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Denwood {ECO:0000313|EMBL:VDP42840.1}, and Denwood, Zambia
RC {ECO:0000313|Proteomes:UP000269396};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the otopetrin family.
CC {ECO:0000256|ARBA:ARBA00006513}.
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DR EMBL; UZAL01028672; VDP42840.1; -; Genomic_DNA.
DR WBParaSite; SMTD_0000808001-mRNA-1; SMTD_0000808001-mRNA-1; SMTD_0000808001.
DR Proteomes; UP000269396; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015252; F:proton channel activity; IEA:InterPro.
DR InterPro; IPR004878; Otopetrin.
DR PANTHER; PTHR21522:SF32; OTOPETRIN-LIKE A, ISOFORM C; 1.
DR PANTHER; PTHR21522; PROTON CHANNEL OTOP; 1.
DR Pfam; PF03189; Otopetrin; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000269396};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 113..136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 142..167
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 411..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 66056 MW; 100DEAF6B7FB04C5 CRC64;
MEFLLIVILV RIRIFSFILL HILTVNLCIW SDAVIKKISK SIGTLAVLNV TVVHKKYELA
ATNYFLPAVP EYCAIAVAVV YELLHRVGQL KQIECQHEKK EEHHVKCVDR GSIGIIIGTV
IICIVMGVVM LLEIWGKKIH NYVYIVHSTE TSILFIIALI FCVIGIWNTR KLKFSVNFSN
QNLDSKLLIV TFFITVTFLV ACILLNIAFL LGNGFNNNEQ QCLKLHLFSA LLELIQVTVQ
NFFINDLFYR CCHDASYQQR KPGRAMIALL SAINFSLWTI YSFQAKHNNI LLSVNKNYVQ
TSELQSLFIY INVALPMVML YRYHSSVCLA IEYIRVYEDE ITRYESMLRG VPHTKLLPFG
SKWEVIESQH PNYSLPANLL TVPRTRALSE PVVTLNPSAF LKEVHTLDKS NTAIHGNHQN
ISSLNEQEEK KQTIKSNKLE QSKSQKYTNQ NKRRTTHISM ELAQYRVNAS EMEHRLAEMK
LKKYKRGKDD HSINEKLTLN RFNPHKEAEP TMSTSLSDSA LSTVRTTDTI NEDDDEDAFT
GGMECDDYER QNPSPESCYY TKTGDSSSAT YLTQSQL
//
