ID   A0A183P303_9TREM        Unreviewed;      1590 AA.
AC   A0A183P303;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=TOG domain-containing protein {ECO:0000313|WBParaSite:SMTD_0000873801-mRNA-1};
GN   ORFNames=SMTD_LOCUS8739 {ECO:0000313|EMBL:VDP46259.1};
OS   Schistosoma mattheei.
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=31246 {ECO:0000313|WBParaSite:SMTD_0000873801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SMTD_0000873801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDP46259.1, ECO:0000313|Proteomes:UP000269396}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Denwood {ECO:0000313|EMBL:VDP46259.1}, and Denwood, Zambia
RC   {ECO:0000313|Proteomes:UP000269396};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the GCN1 family.
CC       {ECO:0000256|ARBA:ARBA00007366}.
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DR   EMBL; UZAL01029148; VDP46259.1; -; Genomic_DNA.
DR   STRING; 31246.A0A183P303; -.
DR   WBParaSite; SMTD_0000873801-mRNA-1; SMTD_0000873801-mRNA-1; SMTD_0000873801.
DR   Proteomes; UP000269396; Unassembled WGS sequence.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 5.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000357; HEAT.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR034085; TOG.
DR   PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR   PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR   Pfam; PF02985; HEAT; 2.
DR   SMART; SM01349; TOG; 1.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   PROSITE; PS50077; HEAT_REPEAT; 3.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000269396};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          200..436
FT                   /note="TOG"
FT                   /evidence="ECO:0000259|SMART:SM01349"
FT   REPEAT          376..414
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          475..513
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          596..632
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REGION          1049..1117
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1055..1111
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1590 AA;  174957 MW;  B102D602B2233CC6 CRC64;
     MGRILCPESP DRWRERIGLA MILTRLSDAP AVSLSTSSSS TSQILFRQSL LIGSNEEKTE
     DNINPNGFDT ENFSSTSDDM SNQSPMWLLN MFRFLVSDGL NDRNTAVQSE MLQAGLRAVR
     NFGKQYIGQI LPILENYVNK APNVPELDSV RQSILILTGS LSQHLDSTDP RVGTIFNRLL
     NTLSFPSDLV QQAVEDSLAS LIGKLSEEQT AKTINKLMTT LLSSNNYAER HGAAHGIAGI
     ARGLGIMSLK HHGIIDKIIP ALDDTKVAKR REGALMAVER LSLGMGRLFE PYVVRLITPL
     LNTFGDTNPG VREAASNAAR AVMSKLSAHG VKLILPALLK AIDDQQSWRT KAEAVDLLAS
     MTHCASKQLS ACLPQIVPRL LEVLVDSQDR VKQAGVRALT QIGKVIRNPE VQALVPLLTN
     CLQQPLADKT PCLAALRDTC FVHVLDAPSL ALILPVIQRA FADRSTETPP YVSTILPLLK
     TCLLDAVPEV RSAAAAALGA VVRGMGETSF SELLPWLMST LTSETSSVDR SGGAQGLAEV
     LGGMGIEKLR VVLPDLIRTV SSESKLQPHI RDGYLMLFIY LPTVFQDDFA EFIGPIIPTI
     LKSLSDETEF LRETALRAAQ RIVHMFSETS LELLLPQLEQ GMTDSNWRIR HSSVQLLGEL
     LYRISGLSGK GTTKTTNEDD TFGTVEAHER LREIIGDERH NRILARLHLS RSDPIIIVRQ
     SAIHIWKIVV PNTPRTLREI MPVLVRLLLD TLGSSSREHQ QIAARALGDV VRKLGERILP
     EIIPLLVTGL DSPDADQRRG VCTGLIEIIR SCQSDLLSNY ADSLLDPIRR TLCDPLVEVR
     RNGGKTFELL YAAIGIRSLD GILPDLLAQL DDPETSHYAL DGIKQLLAVK GKAVMPYLVP
     KLTHPVVNVK AFAYLASVAG EALTKQLGRI LPALLQTVSL MSESDYNQNN ENKDIEEETE
     NEDLEHCAAV LVCIYEATGI RQILNELLSG LSTTVTIDET TNNTTTQNKL VPGSSAYRLA
     CLRLLRAYLE ASFQDSSDVV TSIVKSNVNN KSSDEDETDE SDVDDDDLED EEASDDGSFN
     SDEDYSDEDD MDKDDDDSYD DDDDDEMEEN PDAKEVISRV LNESYPLALR NICRLLASTD
     KTTLSEAWKC LETLFKRWNP ETITSQIGDL RQGIRGAISE MNKLAAANKN EGQKYLPGFS
     DPTLPLVSLV KLYAECTLRG RPAIKEPSAQ GLSECIIHAN GTALQGCVIK VIGPLIRLLG
     ERQTNVVRVA VLQSLTSLVN KCPQSVRPFV TQLQSTFLKC LGDSHKQTRI LGGEGLSSIV
     PITPKLDPLL IDLARVSSQT VVSRFHDYLE DTSSEIEDML PKSGVSATAH TLAGVAAFPD
     TSLQALRLCL EHSRGRAGLT ALNTILHSLI PLMRLPESCG NEIRIETNPH RNNIVDDNEY
     NSEDNDDEQE SVLGSFNQTK QVLISSDQLR IIVSSCIGFI VVAAQATIDN FSQSDNEKIQ
     KKLELVDLFE RKLCLSSSTK QDVQWTFNQS QGIALLIPLK HTPEILINSE TIQSGFCERL
     GQFIKQLSIH ENVSLISTII SICNHNYCAY
//