ID   A0A183SMB0_SCHSO        Unreviewed;       666 AA.
AC   A0A183SMB0;
DT   07-SEP-2016, integrated into UniProtKB/TrEMBL.
DT   07-SEP-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=PKD_channel domain-containing protein {ECO:0000313|WBParaSite:SSLN_0000552901-mRNA-1};
GN   ORFNames=SSLN_LOCUS5358 {ECO:0000313|EMBL:VDL91743.1};
OS   Schistocephalus solidus (Tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Diphyllobothriidea; Diphyllobothriidae; Schistocephalus.
OX   NCBI_TaxID=70667 {ECO:0000313|Proteomes:UP000050788, ECO:0000313|WBParaSite:SSLN_0000552901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:SSLN_0000552901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (JUN-2016) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDL91743.1, ECO:0000313|Proteomes:UP000275846}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NST_G2 {ECO:0000313|EMBL:VDL91743.1,
RC   ECO:0000313|Proteomes:UP000275846};
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the polycystin family.
CC       {ECO:0000256|ARBA:ARBA00007200}.
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DR   EMBL; UYSU01033217; VDL91743.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A183SMB0; -.
DR   STRING; 70667.A0A183SMB0; -.
DR   WBParaSite; SSLN_0000552901-mRNA-1; SSLN_0000552901-mRNA-1; SSLN_0000552901.
DR   Proteomes; UP000050788; Unplaced.
DR   Proteomes; UP000275846; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.5.340; -; 1.
DR   InterPro; IPR013122; PKD1_2_channel.
DR   InterPro; IPR003915; PKD_2.
DR   InterPro; IPR046791; Polycystin_dom.
DR   PANTHER; PTHR10877:SF183; AT14535P-RELATED; 1.
DR   PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR   Pfam; PF08016; PKD_channel; 1.
DR   Pfam; PF20519; Polycystin_dom; 1.
DR   PRINTS; PR01433; POLYCYSTIN2.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275846};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        311..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        349..367
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        401..418
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        438..460
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          131..303
FT                   /note="Polycystin"
FT                   /evidence="ECO:0000259|Pfam:PF20519"
FT   DOMAIN          304..495
FT                   /note="Polycystin cation channel PKD1/PKD2"
FT                   /evidence="ECO:0000259|Pfam:PF08016"
FT   DISULFID        171..184
FT                   /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ   SEQUENCE   666 AA;  76014 MW;  3FB8014EF3704968 CRC64;
     MSVFSKVNQA FVHDPDDTEN DGSKSENLVH EAEQVQLEAE THDPEKDVLG YGDADIHGCW
     HRFMFHLRMA FGILDRNAYH MTHTMQEALM NSKVEGEKLS LATANSIEDF WKPRPILSVK
     VLKGPLLANI YLDKWYNGDV QSGEQVYFIA YDALLLGLPR LRQLRMASNS CTIPQDFQSQ
     ISKCYNAYTV GTEDTSAFGP KNSTAWTYTS PEVLSAGYHW GKMAVYGGGG YYVDLPRNET
     EARQLLNELF ECLWVDRGTR AIFLHLTVYN PNVNLFCVIS LVTEIPASGG IITSGDFRTV
     KLVRYVTTQD FVVMGFECLF LCFLIYYTAE EIIEIYRLRC QYFKGFWNLV DILVILLASV
     CAGFNIYRTY AVQKNLGNLL ASPDVYPNFE RLSYWEMQFD YAVGILVFLV WIKIFKYVSF
     NKTMNQLNLT LCSCAKDIAG FGVMFFIVFF AFAQLGYLAF GTQVTDFATF STSLLTLFRI
     ILGDFDFQAL HEANSRLQEI RKKTKQKKAQ LLEIQNVIDV VDTDGQDMTI DDFKSEMKDS
     AGGFTLEQVF KKADINSDLK LSPAERSALK KTLEHKKMEI IHDMVNYQEA QLGQSFEQVA
     KFFADKTASK EEVNQAFSRL IRLETCIRTV TERIRAMAEK LESVEEAKSK RPDRLVTILE
     NIISVR
//