ID A0A194Q5C2_PAPXU Unreviewed; 760 AA.
AC A0A194Q5C2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE SubName: Full=Venom dipeptidyl peptidase 4 {ECO:0000313|EMBL:KPJ00743.1};
DE Flags: Fragment;
GN ORFNames=RR46_07582 {ECO:0000313|EMBL:KPJ00743.1};
OS Papilio xuthus (Asian swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=66420 {ECO:0000313|EMBL:KPJ00743.1, ECO:0000313|Proteomes:UP000053268};
RN [1] {ECO:0000313|EMBL:KPJ00743.1, ECO:0000313|Proteomes:UP000053268}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Px {ECO:0000313|EMBL:KPJ00743.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ00743.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ459460; KPJ00743.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194Q5C2; -.
DR STRING; 66420.A0A194Q5C2; -.
DR Proteomes; UP000053268; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF135; INACTIVE DIPEPTIDYL PEPTIDASE 10-LIKE PROTEIN; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053268};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 90..400
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 562..726
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:KPJ00743.1"
SQ SEQUENCE 760 AA; 84166 MW; 14C4F47E3420E9F2 CRC64;
ELAAATPTQR NWRGILIALL VIAAVLGLIV FSIALLTPAG DGGRVKGRRP TLNDVLTEHY
KPFNGTWLTG LEVSKKAFMN KIPISPVEDD RSAPLLQYAE WSPVGSSLVF VHDNDIYYKP
RILKTLVCRI TNTGIPGVIF NGVPDFLYET EVLRLDRALW FSPDGQTLLY VTYNDSLVQQ
HKYPWYGLDQ QEPPAYPTIR TLRYPKVNTN NPMVTVYVVS LKTPKFLFPH PIQFTSQVDK
SWYVRWTSWL TEKQIGVLLL NRPQNVSIIS ICSAVHYNCQ DIFRDESDGT RWSGLGADPV
EECGWCGGGA LVGGPAGVFT SAPITDQGGI WRHAVQLTTE TRITLTQGSF EITQLAGWDE
RRRLLYVIGT APEKAGERHL YRVSVPADGS WPPPPHCLTC TYAQPPDTMQ LTTEPPVDEM
EYENSTSSLP SWPTSTVLPH VSHENDTLPT LCLYNRVIFS KNFSYYVQEC LGPGPPATFL
CSANGVRRSV LWDGQPLRQK FAALATPQFK VFRVEVQAHR EARVRLLLPP GLRETDDLPL
PLVLHVSAEP GGQLVTERWR PDWGWYLASA RNFIVAEIDA RGSGGQGEEL RTEIYQKMLS
VDVEDQIAVL SYLRDNLKMV DGSRVGLWGR GYGGGAAAAA AAGDARNVTR CLAAVAPLAD
LRRHNSYWTE RYGGAAAGGA GGAVWRRAGN LPPRRVLLAH ATADERAPPD HALALARAMV
RAQALYTPQT MEQFFDECFG PVELADWDAG GVGGLFPFRD
//
