ID A0A194QQ36_PAPMA Unreviewed; 1089 AA.
AC A0A194QQ36;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Lysosomal alpha-glucosidase {ECO:0000313|EMBL:KPJ07474.1};
GN ORFNames=RR48_08487 {ECO:0000313|EMBL:KPJ07474.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ07474.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ07474.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ07474.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ07474.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family.
CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00779}.
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DR EMBL; KQ461185; KPJ07474.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194QQ36; -.
DR STRING; 76193.A0A194QQ36; -.
DR InParanoid; A0A194QQ36; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090599; F:alpha-glucosidase activity; IEA:UniProt.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd06602; GH31_MGAM_SI_GAA; 1.
DR CDD; cd14752; GH31_N; 1.
DR CDD; cd00111; Trefoil; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 2.
DR Gene3D; 4.10.110.10; Spasmolytic Protein, domain 1; 1.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR030459; Glyco_hydro_31_CS.
DR InterPro; IPR025887; Glyco_hydro_31_N_dom.
DR InterPro; IPR000322; Glyco_hydro_31_TIM.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR000519; P_trefoil_dom.
DR InterPro; IPR044913; P_trefoil_dom_sf.
DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1.
DR PANTHER; PTHR22762:SF131; P-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13802; Gal_mutarotas_2; 1.
DR Pfam; PF01055; Glyco_hydro_31_2nd; 1.
DR Pfam; PF00088; Trefoil; 1.
DR SMART; SM00018; PD; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF57492; Trefoil; 1.
DR PROSITE; PS00707; GLYCOSYL_HYDROL_F31_2; 1.
DR PROSITE; PS51448; P_TREFOIL_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycosidase {ECO:0000256|RuleBase:RU361185};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361185};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 115..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 231..277
FT /note="P-type"
FT /evidence="ECO:0000259|PROSITE:PS51448"
SQ SEQUENCE 1089 AA; 125271 MW; DB3B1C9805EFE024 CRC64;
MPKPNKNEKS RELDDDYEVV SFEEFCDKPS NAKTDLLSLN DNINYRIYYE SLKLPKDGSS
SNIEEAFDRE IEGQKETSLN GPKGGVYTKY QRFSQRRTTL QRAWEQLKNI CPGMLGVGLM
CVLCVAVWLV VGGTLGGAWT EDKYRKLWQR VHPENTERPM TYYEMVVPEV HYHDHNNLST
KNKFNGSEGS RKTPLDDEKY QRLMRPKPIQ VPTEAPETAK YLKRTPEMLR NMCSNVTDNM
RFDCYPQTGA NEEACLKRGC CWKSTSIQGA PYCFYPPNYD TYKFYNMTEN KRGVTAYYAL
NRPSGYPGDF RMVRVDIMFV TGDIINAKIS DAENPRFEAQ YPEIPMVYGS IKTMKYKMVL
ESSSIGFKVV RLSDNVTVFN TQNIGGLILS DKFLQISSLL PTNQIYGLGE RRARFRTVLN
EWKTFTMFNS DQAPVENTNL YGTQPFYLAL EPDGKAHGTL LLNSHAIDVV LQPTPAITYR
TIGGLFNFYM FLGPSPGDVV SQLTEIIGKP FMPPYWALGF HLCKYNYGSL QVTRDVWKSN
RDAGIPLDVQ WNDLDYMKNG NDFTYDDVKF KGLPEFVKEL HEAGMHYMVL FDPGVSAAEK
AGTYPPFDKG LEMNVFIKNS TGQPFVGKVW NKVSTVWPDF THPNATMYWT QMMSNFHKKI
PYDGAWIDMN EPSNFVSGSL YGECAPEELP YTPHYLTNGL KHKTLCMDAH HYAGDHYNWH
NLYGLTEAIA THFALVEIRG SRPFIISRAS FPGLGRYAGH WSGDVDSSWH DLRMSIPELL
SFSLFGIPMM GADICGFRGN TTVELCKRWM QLGAFYPFSR NHNSDSSIPQ DPVSLGAEVV
SSSRTALRMR YSLLPYYYTL FWRAHLHGEL VARPLYFEAY FPAGYWYSLD GTLLTSGWRN
VTEQHMLAVK NDTMMCDIRV VASCLYKSRQ RAWCQRVSVA RALYMCWPHL TAAQARAILY
WDDGLGLQTY DESKYSLVHF ILDKQEFRSE LQWWAYGMPT VNKITIFGQK VPIKNVTINQ
KPCKKPNCEF SYSSNSKIFV IFNINLRLNE PIHIQWMLQE KLKLTELYLI KALTIYIYNN
HHQLTIHLH
//