ID A0A194QUJ7_PAPMA Unreviewed; 904 AA.
AC A0A194QUJ7;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Glutamate receptor 1 {ECO:0000313|EMBL:KPJ09142.1};
GN ORFNames=RR48_15283 {ECO:0000313|EMBL:KPJ09142.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ09142.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ09142.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ09142.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ09142.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1)
CC family. {ECO:0000256|ARBA:ARBA00008685}.
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DR EMBL; KQ461108; KPJ09142.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194QUJ7; -.
DR STRING; 76193.A0A194QUJ7; -.
DR InParanoid; A0A194QUJ7; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
DR GO; GO:0015276; F:ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:UniProt.
DR CDD; cd06380; PBP1_iGluR_AMPA; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 3.40.190.10; Periplasmic binding protein-like II; 3.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR019594; Glu/Gly-bd.
DR InterPro; IPR001508; Iono_Glu_rcpt_met.
DR InterPro; IPR015683; Ionotropic_Glu_rcpt.
DR InterPro; IPR001320; Iontro_rcpt_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR18966:SF600; GLUTAMATE RECEPTOR 1-RELATED; 1.
DR PANTHER; PTHR18966; IONOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00060; Lig_chan; 1.
DR Pfam; PF10613; Lig_chan-Glu_bd; 1.
DR PRINTS; PR00177; NMDARECEPTOR.
DR SMART; SM00918; Lig_chan-Glu_bd; 1.
DR SMART; SM00079; PBPe; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF53850; Periplasmic binding protein-like II; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:KPJ09142.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..904
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5008264638"
FT TRANSMEM 571..590
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..679
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 809..829
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 441..783
FT /note="Ionotropic glutamate receptor C-terminal"
FT /evidence="ECO:0000259|SMART:SM00079"
FT DOMAIN 451..516
FT /note="Ionotropic glutamate receptor L-glutamate and
FT glycine-binding"
FT /evidence="ECO:0000259|SMART:SM00918"
FT REGION 855..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 904 AA; 102366 MW; DB05C587FCAE89AE CRC64;
MVGKKTSLLI IAGSLLFYVG VSAQPFSAEK IVVGAIFDQN TEEIQNVFKY ALTVHNQNIS
SKRLELQAYV DVINTADAFK LSRLICNQFA RGVFAMLGAV TPESFDTLHS YTNTFQMPFV
TPWFPEKVIP PSSGLIDHAV SMRPDYHKAV VDTILYYGWK EIIYMYDSHD GLLRLQQLYQ
TMQPGRTTFR ISLVKRINNA SDAMEFLLSL EQYDRWSNKR IVLDCNAKNA KNILVEHVRK
VQLGRRTYHY MLSGLVMDDH WENEVTEYGA VNITGFRIVD HSRKIVRDFM DGLRRMDPRF
KGTISAQTAL MYDGVQVLMD ALGRLMRKKP DAFRTALRRA AAQANLTKVI DCNPSKSWVI
PFEHGDKISR LIKKTDIEGL TGNISFDEEG HRYNFTLQVV EMTVESAMIQ VATWTDKQGL
TLVSPKYIQL HSPSSLDPNK TYIVTTILQE PYMMQKHETI GYSRKEDQLH GFCKDLFDSI
AKRLKIKYEI RLVKENKIGS ISDSDAWSGL ISEVVKKEAD LAVAPLAVTI EREKLVDFSE
PFLSIDNPVV HTRAPKQLAD TFSFLKPLSK EIWLCILFSF FAVSIVLFLV SRFSPNEWRS
VSISDTHIEQ PLSSTNEIIL HNEFSIWNSF WFSLGSFMQQ GSDVVPRSLS GRIVGTVWWF
FALILVCSYT ANLAAYLIVE RIAEPAQAIQ YASKVHTENY ISALYTLVND PALIPNDETV
IQKNYNVNNE NCKTLTRICR YRHVNFAIAM PKGSPLREGI NLAIVNMKRE GVITKLWQKW
ITMNDKPECE TIKDEETAVT EMTLSQVAGI FYVLVGGLAL ALTVALLEFC QHGRAEAARA
NVSLRAALRA KARLASRSQH KTPPQRTPQR EHDRLGWNGS AFAGVSSYIV LSCTAGCESV
AKNL
//
