ID A0A194R1K3_PAPMA Unreviewed; 1388 AA.
AC A0A194R1K3;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protein still life, isoforms C/SIF type 2 {ECO:0000313|EMBL:KPJ11399.1};
GN ORFNames=RR48_15038 {ECO:0000313|EMBL:KPJ11399.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ11399.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ11399.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ11399.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ11399.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ460883; KPJ11399.1; -; Genomic_DNA.
DR STRING; 76193.A0A194R1K3; -.
DR InParanoid; A0A194R1K3; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR PANTHER; PTHR46001:SF2; PROTEIN STILL LIFE, ISOFORM SIF TYPE 1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053240}.
FT DOMAIN 39..152
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 317..384
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 400..489
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 614..808
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 583..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 590..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 992..1006
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1030
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1122..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1161..1184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1305..1331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1388 AA; 155155 MW; 6E797D631D17F733 CRC64;
MSLTTAVSDE EEAGESAMNS PYKGKQTGAA AASFNCTGAV RKAGFLSVKK WLLRKKHQIE
LARKRGWKGY WVCLKGTTLL FYPCDSREGR SVEAAPKHLI IVDGAIMQPI PEHPKRDYIF
CLSTAFGDAY LFQAPCQVEL ENWVNSIHSA CAAAFARHRG KTGTLHLLQE EIYRLEKAIE
SDHKLKQMAD LQQSVVSDPE TRAQLAVQML QWEENLERLH CEQFRLRCYM ASLQSGELPN
PKSLLTHVSR GTKSTLNKLG VFTVSSFHAF ICARSPSLLN NLLAGRGATK RRAPNLSRSN
SGSSRRSMQM SREESEAAVR VSLPEGTTAT VGVREGMSVE EFLVAACARR SLNALEHFVR
VKKRRDMEDH NYFVPHRSDL IETYLHTHEV VEVCAKILYQ VELQRNTLEQ MWGFSVEAEL
IENAERQDEL CCYVSRVEDK SVAMQNGIIK GDEIMVINGA IVSDLDMMYL ESVLQEELSL
VMMMRSSRTE PPELSGVMRA ATDDIIDSLV CPPPPSEPPV ISDDMISGLI VPAPAWSKEL
YSPETDAHGG DSASIGPPKV SSRTNSFEIE NLLKSAEQVT GWCRSPADTR RGSPTGSLAS
AAATPSRHLS DADKLRKVLL ELVDTERAYV KHLNNLLENY LEPLKKETFL SNAEINALFG
NIQEIVTFQR QFLQNLEEAL EAEPNFHHFE FSNQFKNVLF AVGNAFLYYV NHFKLYSSFC
ASHSKAQKVL HPNEGNQALQ EFLAARNPKQ QHSSTLESYL IKPIQRILKY PLLLQQLRNL
TDVNSEEHLH LVEALKGMEK VAEHINEMQR IHEEYGAIFD HLFRQHQKSC KQPIDLSPGD
LLYYGGVEWL NISDFLGKIK KGLELHAMCF VFKSAVVFLC KERLRQKKKL MGVSSKNNSN
EVEIIRYQVL IPVTEVQVRA SSAKDMDSHF LWELIHLRSQ LQRRSEKVYV LSNSTADFRN
AFLKTIRQII RESVRNMSLP SSRPAPTPPR APHTIERDRD RSKHQVHVMQ GSQTLGKTKK
PKTSGQRLSA GNIEVGDLSR ENSQDADEPP QDVSSDEPTF RTRSKTVNDS SDSSSKRTLP
PPPPTTDTDR STEQGSTEAG SKSEGEDEPP PPPAKRGLGR TPNHLTLSTT STLSAGSTGS
QARLIQSSHQ PTQYQPTMVK ELGKRESHSL KSSPERKSSS CSADKKIKVI RSGSGSSINR
DRSPNRSMDQ SPDRDRVTKV IICKSPNKSS LKQTKSLQKS PRGSFDQSKS PRDSMDKSRS
PQQSFDGARS PRGSIMKSRE NSIDRAKSPK PGPKKGIMRT PQASFDRSPC KSPNVSRRSS
RSSGDKLARI GTNSLDRVTH YSQLAKAEDK AMKMGIVVSK STESIAKTIE HPTCVQCYLS
GKRQSKSS
//