ID A0A194R8Y2_PAPMA Unreviewed; 1711 AA.
AC A0A194R8Y2;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Intersectin-2 {ECO:0000313|EMBL:KPJ12331.1};
GN ORFNames=RR48_11587 {ECO:0000313|EMBL:KPJ12331.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ12331.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ12331.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ12331.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ12331.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KQ460779; KPJ12331.1; -; Genomic_DNA.
DR STRING; 76193.A0A194R8Y2; -.
DR InParanoid; A0A194R8Y2; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053240}.
FT DOMAIN 1302..1493
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 131..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 676..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1231..1258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..146
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 286..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1233..1258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1711 AA; 191443 MW; CDD12D5C620D3300 CRC64;
MYGTVSGPPG SALSKSMKYA ETWLYGSVRT PTPPVRPSVF SSYPEIPGPV LISTPQKPTP
HNYAVILCSC PEYLNGTKKT SSTKVSICKK CKGSRLPLTI AESPRMLVGG TVRGPQVSRD
TGLLRAGTVR VQNSKSRPSI LKSNGDSTDP YDLMRRSRLV PPHEARIGSQ FSTTRSRAKS
ISPCRIKNKP IIPDTLAKSR SKSVSRVNEL WVEEETNAND YKKSILSCDI NPYDLVKSSG
SSKSLAESEF DDEFGDIFPE SLKNKNGKDT RYTKSDSNVK AISGQRIRIS NESSNRSTES
PDFVPDNDLK KSQYKSHETS PSLSLPNIKN EGKKTVSLSK NSSKKILSMS TSNRTKPKSV
SPKRPPRRNR SVRIDDDSES DNQKIPDRNY NRKSLQDLSR NSKYKNQNND TIKSILKKPK
NYSSPDSNAK TETSDDSFDY KRTNFSQFYL PKPNDKGVIS PSNNLNRKRV QFLVEKEETK
VIYTAELNLQ DNTIKDNIEG NKPEQEDFEI VAEGDIVSST LEICDEKATD VITESFKDDK
KVEEENPVIK VETIFENIGT KTSNGETTNT NDHTKSDDNN IPKIPALRRS ESERLSSILS
ISPPKFLDTM ALRSKPKHGH TSQVFLESVT EKSVTNESNI LQIQGLNEQE FQAKHEDEEN
ENLSDNSEIT REVLKNLRRG ISSSPEPPPR LKYKERGKSK KQNYVKARFI RNNSSSSTSD
EWSDGNDCEQ KTVLRVKQFD SDEADEISTS KNFLRINDNE PKKTSIQING SECYSTMNVG
TDTPIYLSSV VVNDDYGNTC NTFQTGTTVT ISVGGPQKDM KKSKSQIYIG AVFSEAEVSI
DESNTYEDIC NDSTKSYDTS GSFNNSTVSD VSSILCDPVE AVKRNLVPHV CGKVTDTSNN
SNEIDETEAV TENQAENGNF VTKLFNDPFF GHLAEGLDTD LVKKLIENSL IKLQETKHQE
GTDSSKGTIE KLIESSLINM KSDLAKDSKQ EEEQQSNEDT SVKKEEVNTS VVVDNDENGC
SAPYESMEYE SGAMGVFSDL EPMSDCYNAS ASELSTEDET NSTRSKFYQM LVDAALCDIE
ISNNADDDHL YESIRLNSDP IYEEIGDMPP PLPVNPPPNS LLIHEDEKRS GSRSIFEGAS
KYDILSYLVD AKERGIDDEE TYITNYGNES EAPALVNESK DKQNSGISKN HLSSNTSQLS
NASDSSEDNS LIISHESLEK TVVCKKTSAE IERNDSGVGS ETSKSSRSRL QGKNSPCNTL
TEKNTPIHLC EDCDTAVETQ ITEQGSVYAP LVCRKCAKKR AERKEIISEI VETEEKYGRD
LQIILEEFYK PMLVAGLLTQ EQLSAIFLNV EELIENNQVL SEKLRDALEI AIEQGDEDLL
TVNVGKILLD CSGMLTAFQS YCVKQAGAAL LLAGLEKEKE LLRIFLRVSQ MENAVLRRMN
LNSFLMVPVQ RVTKYPLLLS RLYRATASCA SEREDVRGAQ RCVESRLEEI NAAAAAAAAA
ARDVPLWRRL AAARRTAHDL HVADIRLRKM AVDVLDWNHD DARFAMEGKL LFTQPNDNNW
RKGRTIKLMP INALLVTNGK PTTTHKTNEI RETREARDRE AREREGEALF ARSGVREAAL
LLVREKAGRY TLQREPLFLD RCVVAADHEP DHFFEVHEIT TKDSYIFKAE ENTRTRTWYL
QLQYHAQGAG AWRKRRNALA NIMINPMLTR N
//
