ID   A0A194RH50_PAPMA        Unreviewed;       420 AA.
AC   A0A194RH50;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   RecName: Full=Malate dehydrogenase, mitochondrial {ECO:0000256|ARBA:ARBA00016075};
DE            EC=1.1.1.37 {ECO:0000256|ARBA:ARBA00012995};
GN   ORFNames=RR48_09288 {ECO:0000313|EMBL:KPJ15261.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ15261.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ15261.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ15261.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ15261.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
CC   -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.
CC       {ECO:0000256|ARBA:ARBA00008824}.
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DR   EMBL; KQ460397; KPJ15261.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194RH50; -.
DR   STRING; 76193.A0A194RH50; -.
DR   InParanoid; A0A194RH50; -.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR11540; MALATE AND LACTATE DEHYDROGENASE; 1.
DR   PANTHER; PTHR11540:SF16; MALATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240}.
FT   DOMAIN          1..123
FT                   /note="Lactate/malate dehydrogenase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00056"
FT   DOMAIN          141..301
FT                   /note="Lactate/malate dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02866"
SQ   SEQUENCE   420 AA;  45959 MW;  BF67E53F7926FDDB CRC64;
     MKVTICGAAG NTGQPLALLL KQSPLLDEIA LYDICPTCGY GMELSHVDTK CKISSFSGRH
     MLCDALKDAK VVVIVARDEE DSFEKSAPII TEIALQICNT CPETFTIVGT EPVESMVPLI
     SEIQRLRNVY NPRKLLGCVE LHCVRANTVL ADFLRVPPES VRVPVIGGAT PNTMVPVLSS
     AVHPGTLTQE HVECVTSCIM GGTEAVCAAK GCKHATASLA GAYALARNTL NVVKGLQGGK
     VEQCAYVDCL GTCAPNCQFF ASEVILGSTG IEKNLGIPEL TKFENCLLCK CLPYVQNEIA
     RAIWLVYTMC QQCTCYCSPS PSECYAPPCM PCAPPTNWTC ECPDSCRDEY LASICREMTC
     RCGNTELCWK PREFDFYTDR ATKGRQRMME HSAACNDCRM PKSVRIEQEI RNRAKTPRCN
//