ID A0A194RKV4_PAPMA Unreviewed; 1559 AA.
AC A0A194RKV4;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Probable ATP-dependent RNA helicase spindle-E {ECO:0000256|ARBA:ARBA00013352};
GN ORFNames=RR48_12020 {ECO:0000313|EMBL:KPJ18172.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ18172.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ18172.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ18172.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ18172.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; KQ460045; KPJ18172.1; -; Genomic_DNA.
DR STRING; 76193.A0A194RKV4; -.
DR InParanoid; A0A194RKV4; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.30.30.140; -; 1.
DR Gene3D; 2.40.50.90; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035437; SNase_OB-fold_sf.
DR InterPro; IPR002999; Tudor.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF113; ATP-DEPENDENT RNA HELICASE TDRD9; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00567; TUDOR; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00333; TUDOR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50304; TUDOR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Helicase {ECO:0000313|EMBL:KPJ18172.1};
KW Hydrolase {ECO:0000313|EMBL:KPJ18172.1};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Spermatogenesis {ECO:0000256|ARBA:ARBA00022871}.
FT DOMAIN 212..378
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 432..623
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1027..1086
FT /note="Tudor"
FT /evidence="ECO:0000259|PROSITE:PS50304"
SQ SEQUENCE 1559 AA; 175349 MW; 77E2E9EB8B831CEA CRC64;
MEELRSFFNN PCPSNAQVKK LRGPITGGRR ITKEDTINEL NKPEQHRHSV LASGTDYAEA
IKKKEMENYL KYEGNRDTFQ SFAGGLDSLE QLSSYSYSMQ NIEALTEEAM NEVYKKYSFQ
RKEDTNNLAI NEYRQQILSS ISAYPVVIIE GPTGCGKTTQ VPQWILDDSF ENRRPCKIVV
TQPRRIAAIS IAKRVAQERG WDVSGVVGYQ ILSSISAYPV VIIEGPTGCG KTTQVPQWIL
DDSFENRRPC KIVVTQPRRI AAISIAKRVA QERGWDVSGV VGYQVALEAK VSSDTRISYV
TTGILLQKLV SAKNMNEYTH VILDEVHERG QEMDFLLLVV KRLLYTVSPH VKVVLMSATI
NRKTFADYFM IPTPMGLQTA ISIKVVKKDP MFTVKTFYLN HLNKFGSILD KITSSKNESP
GIPSEMHHLV IKLIDAFEQI DEKEENFACR SEADLPSVLI FLPGINEIEE LYDCLTNSEL
RSKMSEKTGT SKTKWWVLPL HSTITADEQV RVFQRAPPGQ RKIILATNIA ESSITVPDIK
YVIDYCLMKV LVADTATNFT SLQLSWAAKA NCEQRAGRAG RVRDGRVYRL VLERFYNDLP
DECPPEIVRC PLERLVLLAK MLDMGPPSDI LALAMDPPDM SNIHKTMLVL KEVGGMKKTI
NDEWCVSDGD ITYLGRIMAK LPLDVRISKL IMLGYIYGCF DESIIMAAAM SVKNVFNSPF
REKLNAYNSK LTWADGSTSD CIAFLNVYKV WNHLRKLNYF KQPGSEGQWA RRFYVQVRAL
RELDDLVREL RVRLSREGLD TNAVPSPWAK HEITLVLKLI IAGAFYPQYF VHASTDECRE
REAVRVLGGL NPRRSLYFTG WPTHQPLAPY APAIRNTVRR LLGDDPRVSF DVGSRKIFLT
FSDGSDETKS TEKTGDPTIP GQVVLPVYKA VKARQIRTDF RIPLLPIEKA NELAAAHERA
NTIIDLDKMV PRLPEIDDTH FPLKLSQYIS VSKFWVQYDD ESTVAELREI EAALNRGTLL
ASAGGEKPGV LRAAPYVSAA GTAFYRARIV NTLPRDMLEV LYIDYGSYGR VSTCSVRELP
AGVCSNTPPL AMRCSLTGVA PAPLLDHHAH WTPAADHLFT TLITRGRLLG KVYSVVNGVV
SIELFAEHGK TSVNKALLDK GLAVPCEESY ESKLNHDVRE MANGLNMVQK RAYNKEQIEA
AFYHMNEIDP PNYKECDTDV CLKGPFSPLE ISVHNLMYAG REKQVNIEWN SVNSVLLDTE
PQEIYERLLV AAQVGQNEMG STLTLHHTTL MPNIPGLPAI IALLFCPALL VAAQVGQNEM
GSTLTLHHTT LMPNIPGLPA IIALLFCPAA ELRRDERCTR YVSTLCGLGS HDDGRPYFPE
HDILVNIDVD LDVDDIGLIN HVRHLMDYMM FCSEGQDTPT ADDEFHPKVP KFIREDIMKL
LRKRRKHREP CCVANAWCWR SADESELLEI SVPGMAERAL VFSLHRPLEL HATPRTDLLR
LHAANQALYH MLARTSSSSS QELTCELCNT GPLPAPAMRI HLYSNMHLEK EDDLRDVQS
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