ID   A0A194RNQ0_PAPMA        Unreviewed;      1122 AA.
AC   A0A194RNQ0;
DT   05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Ubiquitin-protein ligase E3B {ECO:0000313|EMBL:KPJ19039.1};
GN   ORFNames=RR48_12550 {ECO:0000313|EMBL:KPJ19039.1};
OS   Papilio machaon (Old World swallowtail butterfly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC   Papilionidae; Papilioninae; Papilio.
OX   NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ19039.1, ECO:0000313|Proteomes:UP000053240};
RN   [1] {ECO:0000313|EMBL:KPJ19039.1, ECO:0000313|Proteomes:UP000053240}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ19039.1};
RC   TISSUE=Whole body {ECO:0000313|EMBL:KPJ19039.1};
RX   PubMed=26354079; DOI=10.1038/ncomms9212;
RA   Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA   Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA   Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA   Wang W.;
RT   "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL   Nat. Commun. 6:8212-8212(2015).
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DR   EMBL; KQ459984; KPJ19039.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A194RNQ0; -.
DR   STRING; 76193.A0A194RNQ0; -.
DR   InParanoid; A0A194RNQ0; -.
DR   Proteomes; UP000053240; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR45700:SF3; UBIQUITIN-PROTEIN LIGASE E3B; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF00612; IQ; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00015; IQ; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:KPJ19039.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053240};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          761..1122
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        1090
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1122 AA;  127934 MW;  36A3DC5FBE688F52 CRC64;
     MFSKSLTSKD TFLEQTKAAR EERALEKKRE TSAIKIQAIV RGWLARQKFV KLILKEFDEL
     LPEVNPHGSQ EEPSPAFELI PALDVYKASC RLFLIFKQQR DRKRLEKLCK YIVQSLHSDS
     VKLSYVGVFL NKEYSLQWIA HIKVLLYKCC LYLEELKPES PIDMQSILIL LHTLIAFTAT
     NTWALTRLKN FDKLRGGMTQ LCANIMGSLF HKGYYLTLKS LLLRGLCREK VSLKNISLTA
     IITLSLRPLV SAQFSEKLLT MYIIQILSVP TLIYHMQQIS PESIAAFRSH AMFDKCLEFL
     STDQNMRIVF NTLEGNYALC LLANLIQMAH LEREHALPES FYPTFVLVVT RFLDSCQQYV
     VLKKSNLSNW HPVLGWFSQS FDAFLPPAMG NLRNQLALLW GGPLLKKIMA TPLKEMVEAG
     VSGEEGAGPS QPSTPIQSMN PAALIRRAIE ARTSRSSSNK NFRRLGSPDS TKAALICSMY
     HTALQTMTQV KLDILTGLCN QDEILYSLWQ FLCTLGPNCG LKSFLDLLAV NTKTSAPEFQ
     MLILFADCMT HYVTILDDME MYEQQDPFKL EDFIVMSQFL NMFVYKSIMG QLFDLKSISS
     NALFSSLHTL LLALYRRDCR RPYAPPHHWL VRDIRDNHFM ADLEKGKKPQ QVLVQKTPHM
     IAHGERVRLF RRAVADEKVV LGLTERACVS GLRSTLVTVR RARLVEDGYR QLAALPARAL
     KAVVVLGLTE RACVSGLRST LVTVRRARLV EDGYRQLAAL PARALKAVVR VRFVNQQGLD
     EAGIDQDGVF KEFLEETIKR VFDPSLNLFR VTSEERLYPS PTSCLQENHL QLFEFIGRML
     GKAVYEGIVV DVPFASFFLS QVLGQTQQAL YSWIDELPSL DRDLYRSLTY IKHFQGDIST
     LELTFSVDEE RLGEIVTHEL VPGGKAIPVT NENKINYIHM MAHFRMHTQI KDQTNAFIKG
     FRTIINPEGA LSCLQRLISG DNVPLDLRDL RRHTLYYGGF HDSHRVVCWL WDVLQRDFTE
     NERAMFLKFV TSCSKPPVLG FAHLKPPFSI RCVEVGDDED TGDTIGSVIR GFFTIRKKDP
     LNRLPTSSTC FNLLKLPNYQ KRSTLRDKLR YAVNSNTGFE LS
//