ID A0A194RQ04_PAPMA Unreviewed; 358 AA.
AC A0A194RQ04;
DT 05-OCT-2016, integrated into UniProtKB/TrEMBL.
DT 05-OCT-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Alcohol dehydrogenase [NADP+] {ECO:0000313|EMBL:KPJ18106.1};
GN ORFNames=RR48_11954 {ECO:0000313|EMBL:KPJ18106.1};
OS Papilio machaon (Old World swallowtail butterfly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea;
OC Papilionidae; Papilioninae; Papilio.
OX NCBI_TaxID=76193 {ECO:0000313|EMBL:KPJ18106.1, ECO:0000313|Proteomes:UP000053240};
RN [1] {ECO:0000313|EMBL:KPJ18106.1, ECO:0000313|Proteomes:UP000053240}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ya'a_city_454_Pm {ECO:0000313|EMBL:KPJ18106.1};
RC TISSUE=Whole body {ECO:0000313|EMBL:KPJ18106.1};
RX PubMed=26354079; DOI=10.1038/ncomms9212;
RA Li X., Fan D., Zhang W., Liu G., Zhang L., Zhao L., Fang X., Chen L.,
RA Dong Y., Chen Y., Ding Y., Zhao R., Feng M., Zhu Y., Feng Y., Jiang X.,
RA Zhu D., Xiang H., Feng X., Li S., Wang J., Zhang G., Kronforst M.R.,
RA Wang W.;
RT "Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.";
RL Nat. Commun. 6:8212-8212(2015).
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DR EMBL; KQ460045; KPJ18106.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A194RQ04; -.
DR STRING; 76193.A0A194RQ04; -.
DR InParanoid; A0A194RQ04; -.
DR Proteomes; UP000053240; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053240}.
FT DOMAIN 59..330
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 84
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 146
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 113
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 358 AA; 39745 MW; 3CF824515180D6BF CRC64;
MSIPESFVLS GGDLMPRIGF GTWQMRELEV LDWAEVARDR ESSRDLLSEA RAHFELMASS
DVLEPAVAAA LEAGYRHFDS ARVYENEAAL GRALNRWIGN DPNKRKELFV VTKLPPGGNR
PDLVAEYFNA SMHDLGLDYL DLYLLHTPFA FEHVPGDLHP MNPDGTIRAD LTTDLIGVWK
AILKLKDSGR VRHVGVSNVN EEQLQRLCAV EKPACLQVEV HMLCQQKALI AAANKLGIPV
VAYSPLGSKA LADALATKTG REYPNLLQLP AVLKIAQAHN KTPAQVLLRH LLQSGVAAIP
KSTHPERIKQ NISVWDFELS DEEMSELGAL DRGEQGRICD FSFFPGIEKH PEFPFKKS
//
