ID A0A1B8Y0E8_XENTR Unreviewed; 1433 AA.
AC A0A1B8Y0E8;
DT 02-NOV-2016, integrated into UniProtKB/TrEMBL.
DT 02-NOV-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Voltage-dependent calcium channel alpha-1 subunit IQ domain-containing protein {ECO:0000259|SMART:SM01062};
DE Flags: Fragment;
GN ORFNames=XENTR_v900283471mg {ECO:0000313|EMBL:OCA16407.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:OCA16407.1};
RN [1] {ECO:0000313|EMBL:OCA16407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA16407.1};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Ottilar R., Schmutz J., Salamov A., Cheng J.F., Lucas S., Pitluck S.,
RA Gundlach H., Guo Y., Haberer G., Nasrallah J., Mayer K.F.X.,
RA van de Peer Y., Weigel D., Grigoriev I.V.;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OCA16407.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA16407.1};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3] {ECO:0000313|EMBL:OCA16407.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Nigerian {ECO:0000313|EMBL:OCA16407.1};
RA Sessions A., Jenkins J., Mitros T., Lyons J.T., Dichmann D.S., Robert J.,
RA Harland R.M., Rokhsar D.S.;
RT "WGS assembly of Xenopus tropicalis.";
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KV460615; OCA16407.1; -; Genomic_DNA.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 2.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005447; VDCC_N_a1su.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF6; VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1B; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 2.
DR Pfam; PF00520; Ion_trans; 3.
DR PRINTS; PR01631; NVDCCALPHA1.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 389..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 427..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 459..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 581..603
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 693..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 774..792
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 804..827
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 896..923
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1048..1082
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 48..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1183..1311
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..111
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1192..1216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1225..1240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1241..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:OCA16407.1"
SQ SEQUENCE 1433 AA; 162800 MW; 91B6CA9B3E216B74 CRC64;
KQQNSTKCRS VWEQRTSQIR KHNFRASCEA LYSELEPEDR LRYATTLHLR PDMKSHMDRP
LLVEPQDSTE TKDGSPDAPA PNEIEPVPGV TTEPSARKQH RHRDRGEPNG GGRENGNHNG
DSGSNDREER QRQHRSRSKE EDGSKETGRG ERNRSQERGK RHHRRASPED GTEREHRRHR
THRHSADRQG KEGNGQPPSG GKGERKSRHR GGGSRSGNRE GEGTNRGTGE NGEEPPRSRH
RNRHKALSTY DTEDKKENKD GESAEKEHRN HRPRENRNES ELPPGGLQQL AEQPEDADNQ
KNVNRMALPH PERSSTINIP VTITAPPGES AVIPINNVDF DGKSEEKKEM EDDLTKNGPK
QILPYSSMFI FSTTNPVRRL CHYIVNLRYF EMVILVVIAL SSIALAAEDP VQADAPRNDV
LKYMDYIFTG VFTFEMVIKM IDLGLLLHSG SYFRDLWNIL DFIVVSGALV AFAFSGNKGK
DLNTIKSLRV LRVLRPLKTI KRLPKLKVRD SSLLPSFLNP TKLSMDLWLP HVADQQGYKK
VSAVSDWPTR MPGKLPPLTL PLMFSVYQAV FDCVVNSLKN VLNILIVYML FMFIFAVVAV
QLFKGKFFYC TDESKDLEKD CRGEYLNYEN NDVRAQAREW KKYEFHYDNV LWALLTLFTV
STGEGWPNVL KHSVDATYED QGPTPGFRME ISIFYVVYFV VFPFFFVNIF VALIIITFQE
QGDKVMSECS LEKNERACID FAISAKPLTR YMPQNRQSFQ YKMWRFVVSP PFEYFIMVMI
ALNTIVLMMK FYGAPQTYED MLKCLNIIFT SMFSLECILK IIAFGVLNYF RDAWNVFDFV
TVLGSITDIL VTEIAENFIN LSFLRLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC
LLIAMLFFIY AIIGMQVFGN IALSDDSSIN RHNNFRTFFQ ALMLLFSCRI HYKDMYNLLR
VIAPPLGLGK RCPSRVAYKV CNLIGRIGYT DMYEMLRHMP PPLGLGKKCP ARGIKQHECD
AELRKEVSSV WPNLSQKTLD LLVPPHKPDE LTVGKVYAAL MIFDFYKQNK NNRDQSHPQS
GVLSQVTTNW MWPDQDMGIR ESSSWGTQPA TDPFSTPRST AFQRGHSEEI HAQRNGKQSV
EMKQIGQTLS NGGEHPTGLE SQGRAVSMPR LAAETHMDLE EQTAHCPILI LKEDAPTRDR
KHERGRSQER KQQPPSSSEK QRFYSCDRYG SRDSGHPRQC DHSRATSPSA GQDHSTHRQG
SGSASGSPRL TSSGASTPCR GIRRQLPQTP LTPRPSVTYR TAHSSPVHFG GPAYSPGRLS
RGLSEHNTLL YSDSPSHSAC TVTRIGSDPY LGPRQDSDSY CPLSEETLTF EEALASNSGR
SSRTSYVSSL TSHSHQLCRV PNGYHYTLGL STGPATAPRG RSYYHEADED DWC
//
