ID A0BK57_PARTE Unreviewed; 644 AA.
AC A0BK57;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN ORFNames=GSPATT00029554001 {ECO:0000313|EMBL:CAK58924.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK58924.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK58924.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK58924.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- COFACTOR:
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000256|ARBA:ARBA00001941};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the transketolase family.
CC {ECO:0000256|ARBA:ARBA00007131}.
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DR EMBL; CT867999; CAK58924.1; -; Genomic_DNA.
DR RefSeq; XP_001426322.1; XM_001426285.1.
DR AlphaFoldDB; A0BK57; -.
DR STRING; 5888.A0BK57; -.
DR EnsemblProtists; CAK58924; CAK58924; GSPATT00029554001.
DR GeneID; 5012106; -.
DR KEGG; ptm:GSPATT00029554001; -.
DR eggNOG; KOG0523; Eukaryota.
DR HOGENOM; CLU_009227_3_0_1; -.
DR InParanoid; A0BK57; -.
DR OMA; HKVYCLC; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IBA:GO_Central.
DR GO; GO:0004802; F:transketolase activity; IBA:GO_Central.
DR CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR CDD; cd02012; TPP_TK; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR020826; Transketolase_BS.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR005474; Transketolase_N.
DR PANTHER; PTHR43195:SF1; FI06132P-RELATED; 1.
DR PANTHER; PTHR43195; TRANSKETOLASE; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
DR PROSITE; PS00802; TRANSKETOLASE_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 335..500
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 644 AA; 70806 MW; D2821302A2EE8619 CRC64;
MSDRVTRKGK SQPQKEEPKQ AKKQKVQKES YDVVQLQDIA HQLRIHSIEM TIASNSGHPT
SCASMAEIMA VLFFTKAGMH FNPKDPGNFG NDRFVLSKGH AAPILYAAWS MVGYIDKAEL
LNLRKIDSLL EGHPVPKLPF VDVATGSLGQ GLSVAGGMAY SSKFLDKIDN RYWVLMGDGE
TAEGSVWEAA HLASHYKLDN LTAIVDVNRL GQSEETSIGH DTNVYKKRWE AFGWKTIVVD
GHNLNSLTDA FEQCRNVKNQ PQVIIAKTFK GKHLEMENKE DWHGKPVPQA QVDFVKKQMK
QQDGFTLAPE VPTSIDRPQQ SHFTVEVNYA VDGKQSTREA YGKALVGLSK SDANQQIVAV
DGDTKNSTFS IKYKEAVPTN FVECFIAEQN MVGWAQGFSC RGKVAFASTF AAFFARAFDQ
IRMGGISESQ VKYVGSHAGV SIGEDGPSQM GLEDIALFRT IPNCVVLYPS DGVSAERAIE
LVANHKSACY VRMSRPSLPI LYPNNEVFEI GKSKILKQND DDKILLIGGG VTTHEIFKAA
KQLSEQDKVH VTVLDLFSVK PLDHDGILNA ANKTALKTIL VVEDHYSEGG LFEAVSSALS
LDKQIKIHSI HVDKVAKSGT PAQMLSLYHL DAAGIIAKVK SIIQ
//
