ID A0C8L6_PARTE Unreviewed; 793 AA.
AC A0C8L6;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GSPATT00036267001 {ECO:0000313|EMBL:CAK67133.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK67133.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK67133.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK67133.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
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DR EMBL; CT868050; CAK67133.1; -; Genomic_DNA.
DR RefSeq; XP_001434530.1; XM_001434493.1.
DR AlphaFoldDB; A0C8L6; -.
DR STRING; 5888.A0C8L6; -.
DR EnsemblProtists; CAK67133; CAK67133; GSPATT00036267001.
DR GeneID; 5020315; -.
DR KEGG; ptm:GSPATT00036267001; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_354305_0_0_1; -.
DR InParanoid; A0C8L6; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43719:SF28; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK2; 1.
DR PANTHER; PTHR43719; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 102..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 380..631
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 681..793
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 731
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 793 AA; 92471 MW; 361217AE35935B81 CRC64;
MKYLLQISRN LQPENAFLNA TLNFRDQDVQ NSFKTFQKKL NKCPMIFIET FKMFLELALT
ISAIFKDNQS VESQILIVFP LSSLLQIWSI QRNSTCNDYW KIIHVVTILI YLSLYVDQFM
INGYVQLYYM YVTQSLNNKK YLICYFTIMQ FTYLYFDNIF DWILLPFEWI FILAISISIY
LRERRKLICF FEKFNFSHDL SYQEVVLNHS LQQNLFVIKL NSDQNMQDQF EVLFVNQACN
KEFATIESIY QKINQIQIIN CNESNISLCN LKVNLTQELI LNNLKATGEQ INMIDNPQSL
NYILYQYMSN SQDKELQESL PLKLTGLMYN NHHQTYDILV SPCIWKYQKS FVVSLIEITD
RIKISQLEKL DQYKDSVLAT VSHDLKNPIG VVQSMITLVQ DKILEKIQSC CNYLEMCQTN
VQILQSFVND LQDFSQIKQQ KLKLAISEFD ILQLIQDVKN VFRIQTQKKN LQLEIVSILK
STQILNNDPL RIKQVLFNLL SNAIKFTSKG KISIIFSDEP MDICKFCINV KDQININKSV
VDVDPLIRNQ QRLILCTVYD SGSGITQEIQ RRLFRNFATY DDDNNTNKNG VGLGLIICKQ
LCGYIGPLQY IYLESQVGVG STFQFVIYKN YDKQQHHQQQ DQFSVDSIDY DVSVHSPYKN
MISTNQLAPF HKKINKKEKL QVLIVDDESF NNMLLKIQLS KIGIYKVDTA FGGQIAIDMV
LKQRYDVVFL DFNMPGMNGL QCINEIKRIS PTTKIYMLTA FNDMKTQQNC LSAGADKILQ
KPPTSQDLKL LFI
//
