ID A0CTU2_PARTE Unreviewed; 2076 AA.
AC A0CTU2;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE SubName: Full=Chromosome undetermined scaffold_27, whole genome shotgun sequence {ECO:0000313|EMBL:CAK74209.1};
GN ORFNames=GSPATT00010443001 {ECO:0000313|EMBL:CAK74209.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK74209.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK74209.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK74209.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CT868174; CAK74209.1; -; Genomic_DNA.
DR RefSeq; XP_001441606.1; XM_001441569.1.
DR STRING; 5888.A0CTU2; -.
DR EnsemblProtists; CAK74209; CAK74209; GSPATT00010443001.
DR GeneID; 5027391; -.
DR KEGG; ptm:GSPATT00010443001; -.
DR eggNOG; KOG2301; Eukaryota.
DR HOGENOM; CLU_001310_0_0_1; -.
DR InParanoid; A0CTU2; -.
DR OMA; VIMIRSS; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0098703; P:calcium ion import across plasma membrane; IBA:GO_Central.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF7; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 139..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 931..952
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 964..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 993..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1041..1070
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1119..1140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1251..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1275..1299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1311..1337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1357..1386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1430..1452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1472..1496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1551..1568
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1580..1605
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1617..1634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1678..1706
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1752..1779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 99..366
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 929..1157
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1246..1500
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 1549..1786
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 554..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 562..588
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..765
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 316
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1444
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
SQ SEQUENCE 2076 AA; 241539 MW; BD911167D285D516 CRC64;
MILQQVKEIW KESDLSKDDG ILQILNDFKE EILDDLEDEY EPEYRAIQVQ ENINIDLVPM
NEVQKALIYD DKYPFLKIRK RILIQAKKIS MMAMQLTKHP IFEFFTLLVI IFNSIMLALD
DPTTDIQTPF QDLMDIIFLA VYTFEAVLKI IAMGFVFNSN TYLRDLWNVL DFTVIVTAYI
PYFVNNSGLQ LSALRSLRVL RPLRTISSVK SLRSIMMTLF ASFAELGNSL IILGFTYTIF
AIAGLQLFSG YAKLRCFDEN GIIQMSGYDT DEPFCNGSCP ENYICGKMMD NPINGLLSFD
DFGLAFLQVF IITTLEGWTT IMQTIMTTFS QFSVFYFLLC VIIGAFFLVN LTLAIIKINF
SKAESQEPIK PDDVSYNLKQ MKRLGIYKFT RDSQTPSITR KHTIRMTRLR QSINNQNNIN
INVANKQIDE PKRSSIKVNF QPLNIKDFSK PHQVKYNNNR ILLQGIQGVR TEQPVSKYQE
ANNPQLIMKT SVQSVNAPQI RKLSKLGTQF KQSQRKMSIT HQEDSPLEEL DNLLKFAVRR
QSVLRVDTKI MASPRIPTPS KETPLPVSSS SMLDESQSPG KPHQSNFLGI PKQQFNFLQD
QKSFNENDVL SVTLSEIDSI SDSELNQRFK EFEISFQIEK SDDKTANETE DRKPIQHIHQ
KRRKQDAPLI YELSKEDEKL KIRLFQSKLV PRVVYKEFHS ESSKDILVSL EIKKQRKDQE
IRNLRIQNMK FTLKYQFQNN STKLSLSKTS QQQQSKSSLS SNDQKLKETV KSRKIIPLTE
IPSVQEITTP KLNVRKQQKR KTIVHKVFTY EQYQSGFNHS SEVDANFNEK LEEVETQQLT
FKTPNETYFY TQTAFQQYHQ IKNDDINLSN GNLVGQASIE DVIMIRSSLQ KRFNFILQGM
NFTKQDYMIY MTKDMLKMLQ FKLFLIVDSR YFNMMLNLAV FINTVILCLD GLVNNSEDLN
DFNLAFTILF TIEMGLKMIG FGIIQYIRDP MNIFDALIVA LSLIDIFFLS GSSVFKSVRI
FRAFRVLRVT KLMRSLKFMN FLVQVLSNAF QSLMYIFLLL ILFIYIFTLL GMSFFGGQLT
YTPSRQSYDT FYESFLVVFQ VLTLENWNSI LYDLLKQPVS WIITMIYLIA WIFIGSYVLL
NLFLASLLDQ FEAEYLREHS LENSNQEGEQ IQQQQIQQTQ TMNQTVVNMS VNQTLNPILA
KQLLTRQDSL NKFIYFSEPG LCFYSLNIFS QNNPIRRLCY KIVKNSLFDQ IILFAIFLSS
LKLVIDTYVS NFLDWADWFF ALFFGVEFLF KIIAYGFVME ENAYLRESWN ILDFIIVVCS
FIDISVASID LSFVKILRLL RTLRPLRLIS QNKSMKLLVT TLINSISGIV NVGVVVILVF
LMFAILGVNL EKGKMNYCDI GSDEQSYLHK ADCISEGYEW KNRDMNFDNV FWAMLTLFIV
STQEGWPTQM YWFVDADESG PIKNNQMWFT SYFLIFLLIG SILLMNMFVG VILVNYKLAE
DEMKDKNVSR DQEDWISIQK LIVDSNPNFA LYYPPKNQYR ALIFKIISNK IFDFFIMLCI
IVNIAAMASN YEGSSVKYQY ILETLNLVLS VIFIFESLLK IIGFGPRGYF RNNWNQFDFF
VVLSSILDMI LSFTDNKDNP ILSAGPQLIR VFRVLRVTRL FRLVKSLHSL KKLIDTALFS
LPALFNVSAL MFLLYFIFSV LGVFLFSNLS DGYIINSENN FNDFHHALIL LFRCTTGEDW
YLLMYDVMNK ASYYYCSYFI IFVVIMQRIM LNLFVLIILD QYERFYFNSD NPLQRFQEFE
DDFVDGWAPL ASETKGQQIH QDQLVQLMLS IKAPMGYDLK EKINTAVNDW KTYNSDAEKS
SQNLEKIKVM VTTEAKKAVA KTIMNMQIES DENQMLEYHY VLFAFMKNFQ TDLFKEVTQA
GLHKLIQREE QTLNKIKKNR HSSQEVNPCV ELLFHIMCFK AYKRYAIKLK ERMNRQQNEF
SQKSSDSSYL HKSSDIVQRD SISQSLESIQ ESKQQFCLPP DLAVYQSDVN IAIKDNSQNT
KNRGSVQQLV EQKLENISEF NSEQSISFNK LNDISN
//
