ID A0D7J3_PARTE Unreviewed; 770 AA.
AC A0D7J3;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=GSPATT00002052001 {ECO:0000313|EMBL:CAK79010.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK79010.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK79010.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK79010.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CT868318; CAK79010.1; -; Genomic_DNA.
DR RefSeq; XP_001446407.1; XM_001446370.1.
DR AlphaFoldDB; A0D7J3; -.
DR STRING; 5888.A0D7J3; -.
DR EnsemblProtists; CAK79010; CAK79010; GSPATT00002052001.
DR GeneID; 5032192; -.
DR KEGG; ptm:GSPATT00002052001; -.
DR eggNOG; KOG0519; Eukaryota.
DR HOGENOM; CLU_358824_0_0_1; -.
DR InParanoid; A0D7J3; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17546; REC_hyHK_CKI1_RcsC-like; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR PANTHER; PTHR43719:SF28; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK2; 1.
DR PANTHER; PTHR43719; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 304..527
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 636..756
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT MOD_RES 690
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 770 AA; 88765 MW; D7FF9E8D655ED7C3 CRC64;
MNSCIKSIGN AKILQIMLIA DSLLIHIQSY LISNYNYLII ALSLTCFHGI VLTFEHFLKG
KNKLFNSLFN AFKGVAQIIV HYLLEQNWLI FAGIQLVCLL KQDVLHVNYV SSIFFITQIF
CVAFSKKDFI IIGVIRTVFN YLFISQIFRI EKQNKLIQLE NLLKHIQHNE FCLLDSNFNP
IFQLQFFNEL KGEQVVGGQE FYNQTRIITP RDNTTNLIRD MPSNFEDEMK QTLSIQEILY
HVKKSKVHLK KKLYYQLNNS NYNISIENIL LDDYNSIVMI QKNKQFENSQ SSNKINFMIK
TVRKVSHDMR NPLNAIINMQ MCLKDYIDQE LVLKYLKPSL NSCHLLLNLI NDILDQAQVE
NKKLKLVYKK FNLEKLICKT ISIFDSLKDK KDINITFNYD SKLPILVNSD KFRIRQIIMN
LLSNAIKYTR PSGEVYIDCS ESSQRKNFIR ISIQDTGYGI KPENLQYLFK EYSKIEDGEN
QNLNPFGVGL GLMISNELAK LLSNNGIQVQ SEFGIGSKFY FEIENKQLPP EDISESQLLI
NHQNGLPSLD VHFFTGLNSQ KSPTISLALP QIESSKKIIL KKSQKTITLM NNSVHNLTKH
KGKNDEKSIA RKSSLSAKQV EMLIQKWYVS TNYKPPVLIV DDDEINILVL QYLLEQMDIS
SDSAMNGMTC LQKFVERQND GISYQLVFLD INMPVMDGYE LAKKLIQIDP LIILIACSGD
ASDQHQLEQC KQSGILGCIL KPILKNNLKE LLVKLSEGIK HDSQQFSYYC
//
