ID A0DL23_PARTE Unreviewed; 792 AA.
AC A0DL23;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Protein HIRA {ECO:0000256|RuleBase:RU364014};
GN ORFNames=GSPATT00018057001 {ECO:0000313|EMBL:CAK83740.1};
OS Paramecium tetraurelia.
OC Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC Oligohymenophorea; Peniculida; Parameciidae; Paramecium.
OX NCBI_TaxID=5888 {ECO:0000313|EMBL:CAK83740.1, ECO:0000313|Proteomes:UP000000600};
RN [1] {ECO:0000313|EMBL:CAK83740.1, ECO:0000313|Proteomes:UP000000600}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Stock d4-2 {ECO:0000313|EMBL:CAK83740.1,
RC ECO:0000313|Proteomes:UP000000600};
RX PubMed=17086204; DOI=10.1038/nature05230;
RG Genoscope;
RA Aury J.-M., Jaillon O., Duret L., Noel B., Jubin C., Porcel B.M.,
RA Segurens B., Daubin V., Anthouard V., Aiach N., Arnaiz O., Billaut A.,
RA Beisson J., Blanc I., Bouhouche K., Camara F., Duharcourt S., Guigo R.,
RA Gogendeau D., Katinka M., Keller A.-M., Kissmehl R., Klotz C., Koll F.,
RA Le Moue A., Lepere C., Malinsky S., Nowacki M., Nowak J.K., Plattner H.,
RA Poulain J., Ruiz F., Serrano V., Zagulski M., Dessen P., Betermier M.,
RA Weissenbach J., Scarpelli C., Schachter V., Sperling L., Meyer E.,
RA Cohen J., Wincker P.;
RT "Global trends of whole-genome duplications revealed by the ciliate
RT Paramecium tetraurelia.";
RL Nature 444:171-178(2006).
CC -!- FUNCTION: Required for replication-independent chromatin assembly and
CC for the periodic repression of histone gene transcription during the
CC cell cycle. {ECO:0000256|RuleBase:RU364014}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364014}.
CC -!- SIMILARITY: Belongs to the WD repeat HIR1 family.
CC {ECO:0000256|RuleBase:RU364014}.
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DR EMBL; CT868485; CAK83740.1; -; Genomic_DNA.
DR RefSeq; XP_001451137.1; XM_001451100.1.
DR AlphaFoldDB; A0DL23; -.
DR STRING; 5888.A0DL23; -.
DR EnsemblProtists; CAK83740; CAK83740; GSPATT00018057001.
DR GeneID; 5036922; -.
DR KEGG; ptm:GSPATT00018057001; -.
DR eggNOG; KOG0973; Eukaryota.
DR HOGENOM; CLU_354306_0_0_1; -.
DR InParanoid; A0DL23; -.
DR Proteomes; UP000000600; Partially assembled WGS sequence.
DR GO; GO:0000417; C:HIR complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR031120; HIR1-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13831; MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS; 1.
DR PANTHER; PTHR13831:SF0; PROTEIN HIRA; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|RuleBase:RU364014};
KW Nucleus {ECO:0000256|RuleBase:RU364014};
KW Reference proteome {ECO:0000313|Proteomes:UP000000600};
KW Repeat {ECO:0000256|RuleBase:RU364014};
KW Repressor {ECO:0000256|RuleBase:RU364014};
KW Transcription {ECO:0000256|RuleBase:RU364014};
KW Transcription regulation {ECO:0000256|RuleBase:RU364014};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221,
KW ECO:0000256|RuleBase:RU364014}.
FT REPEAT 98..139
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 792 AA; 92579 MW; 3956437A5011F005 CRC64;
MSVRIKYTSI IEAKTGLKSL GLSKKNILAL GSGEEEDWLL LNEVNAQFNL HPIQIGKMEK
RMISQLAWSP SGLYLATSND KLIVWQFNGG NLSISRTYQG HKLEITALCW SPDDQRIATA
SLDGNIFIYH IKQDGIQHKI DCGQKTVGIC WDPFDKYIVS LKFDNTVQIF KYKVNFYKID
NWKQEITVSL QIHGKQCTTK REDRKLDWSV DCRYLAVPNL DDKTIPTVAI LDRNQNFQVV
RTIIGPFSSI NVVRFSPMLF KNIIAIGDND GNISLWQINE NQVDEQPFLL VKGHKKAGEL
IEDITWNQQG TVLMATTSKK YIIVIDFQLS LGQVLNETEK QQAIKSLYGD LKNTIKQIRF
YQPKINNDNI KFADMQLENI DVQDELKNQI PDSAFQQREI LKQTQTQFKQ IIVDGKKKLI
PLDVNSSEPV FKKVEQQQPL LIIQQYEILP KSYSFSMNNK SLLLEVQKQQ QRIFNQAVYG
TLIRCIENNT PKWIDYVEGQ IKNIQYNDDL IVIYTDQALL YIENHKGMRQ ESPFILPFLS
QIVLSPKNYI LCLQNTGEFK VINLNTKTIS YEGDIKILMQ HVYEWMDQKQ LFNEDEKKGK
QSIDPLIKAN LKIDTEGYPL VEFLFKDYCV YTYHKQLRQW IKTKQIDVNN QNQDIKNLKK
FNFNQYQTPP YNDAQIYKRI IQKSTIEDAI NDIQQISKLE EQLKIYWSDG DIKTYEKALY
TYIKKLCDTW PNNQEKLSNI IETIITNYNS AEYKYLSERV QDMEELKKKI IYILQQFPQT
RDLTLCLFPD HF
//