ID A0ELZ0_MERUN Unreviewed; 110 AA.
AC A0ELZ0;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Insulin {ECO:0000256|RuleBase:RU000406};
GN Name=Ins {ECO:0000313|EMBL:ABB89751.1};
OS Meriones unguiculatus (Mongolian jird) (Gerbillus unguiculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Gerbillinae; Meriones.
OX NCBI_TaxID=10047 {ECO:0000313|EMBL:ABB89751.1};
RN [1] {ECO:0000313|EMBL:ABB89751.1}
RP NUCLEOTIDE SEQUENCE.
RA Shiao M.-S.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ABB89751.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18245324; DOI=10.1534/genetics.108.087023;
RA Shiao M.S., Liao B.Y., Long M., Yu H.T.;
RT "Adaptive evolution of the insulin two-gene system in mouse.";
RL Genetics 178:1683-1691(2008).
CC -!- FUNCTION: Insulin decreases blood glucose concentration. It increases
CC cell permeability to monosaccharides, amino acids and fatty acids. It
CC accelerates glycolysis, the pentose phosphate cycle, and glycogen
CC synthesis in liver. {ECO:0000256|ARBA:ARBA00002985,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SUBUNIT: Heterodimer of a B chain and an A chain linked by two
CC disulfide bonds. {ECO:0000256|RuleBase:RU000406}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU000406}.
CC -!- SIMILARITY: Belongs to the insulin family.
CC {ECO:0000256|ARBA:ARBA00009034, ECO:0000256|RuleBase:RU000406}.
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DR EMBL; DQ250571; ABB89751.1; -; Genomic_DNA.
DR AlphaFoldDB; A0ELZ0; -.
DR Ensembl; ENSMUGT00000027265; ENSMUGP00000023789; ENSMUGG00000019885.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd04367; IlGF_insulin_like; 1.
DR Gene3D; 1.10.100.10; Insulin-like; 1.
DR InterPro; IPR004825; Insulin.
DR InterPro; IPR016179; Insulin-like.
DR InterPro; IPR036438; Insulin-like_sf.
DR InterPro; IPR022353; Insulin_CS.
DR InterPro; IPR022352; Insulin_family.
DR PANTHER; PTHR11454:SF9; INSULIN; 1.
DR PANTHER; PTHR11454; INSULIN/INSULIN GROWTH FACTOR; 1.
DR Pfam; PF00049; Insulin; 1.
DR PRINTS; PR00277; INSULIN.
DR PRINTS; PR00276; INSULINFAMLY.
DR SMART; SM00078; IlGF; 1.
DR SUPFAM; SSF56994; Insulin-like; 1.
DR PROSITE; PS00262; INSULIN; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277,
KW ECO:0000256|RuleBase:RU000406};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526,
KW ECO:0000256|RuleBase:RU000406};
KW Hormone {ECO:0000256|ARBA:ARBA00022702, ECO:0000256|RuleBase:RU000406};
KW Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|RuleBase:RU000406};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..110
FT /note="Insulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002625086"
FT DOMAIN 28..109
FT /note="Insulin-like"
FT /evidence="ECO:0000259|SMART:SM00078"
SQ SEQUENCE 110 AA; 12324 MW; E7EB5B28E1FC87C7 CRC64;
MALWMRLLPL LAFLILWEPT PAHAFVNQHL CGSHLVEALY LVCGERGFFY TPKFRRGVED
PQMPQLELGG SPGAGDLQAL ALEVARQKRG IVEQCCTGIC SLYQLENYCN
//
