ID A0EPX7_PNEJI Unreviewed; 206 AA.
AC A0EPX7;
DT 28-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 28-NOV-2006, sequence version 1.
DT 08-NOV-2023, entry version 42.
DE RecName: Full=Dihydrofolate reductase {ECO:0000256|ARBA:ARBA00018886};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN Name=DHFR {ECO:0000313|EMBL:ABB84714.1};
OS Pneumocystis jirovecii (Human pneumocystis pneumonia agent).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=42068 {ECO:0000313|EMBL:ABB84714.1};
RN [1] {ECO:0000313|EMBL:ABB84714.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=12L {ECO:0000313|EMBL:ABB84714.1};
RA Kovacs J.A., Kutty G., Achaz G., Maldarelli F., Atzori C.;
RT "Inferred sexual recombination in the opportunistic fungus Pneumocystis
RT jirovecii.";
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|RuleBase:RU004474}.
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DR EMBL; DQ269957; ABB84714.1; -; Genomic_DNA.
DR AlphaFoldDB; A0EPX7; -.
DR UniPathway; UPA00077; UER00158.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR017925; DHFR_CS.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS00075; DHFR_1; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 6..204
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 206 AA; 23379 MW; E2761202A85CA814 CRC64;
MDWQKSLTLI VALTLSRGIG LKNDLPWKLK SDMMFFSRVT SGLLVTRSTG QMNVVLMGRK
TRESLPAHSR PLKNRINVVI SRQEVLDLGG GAYHARSLDD ALALLSQIYD STSKIQLNRV
FVIGGGELYK AAMEHSRLNR IIATVIHNEV DCDVFFPIDF RSSQSCLPWR KQDHSVLEAW
VGSKVPQGKI NENGFIYEFE MWIRDI
//
