ID A0JHM3_9EUKA Unreviewed; 401 AA.
AC A0JHM3;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Tubulin alpha chain {ECO:0000256|RuleBase:RU000352};
DE Flags: Fragment;
GN Name=tuba {ECO:0000313|EMBL:CAJ87187.1};
OS Telonema subtile.
OC Eukaryota; Eukaryota incertae sedis; Telonemida; Telonema.
OX NCBI_TaxID=232287 {ECO:0000313|EMBL:CAJ87187.1};
RN [1] {ECO:0000313|EMBL:CAJ87187.1}
RP NUCLEOTIDE SEQUENCE.
RA Shalchian-Tabrizi K., Eikrem W., Klaveness D., Vaulot D., Minge M.A.,
RA Le Gal F., Romari K., Throndsen J., Botnen A., Massana R., Thomsen H.A.,
RA Jakobsen K.S.;
RT "Telonemia, a new protist phylum with affinity to chromist lineages.";
RL Proc. R. Soc. Lond., B, Biol. Sci. 0:0-0(2006).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC consisting of laterally associated linear protofilaments composed of
CC alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC GTPase activity of alpha-tubulin. {ECO:0000256|RuleBase:RU000352}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; AM237835; CAJ87187.1; -; Genomic_DNA.
DR AlphaFoldDB; A0JHM3; -.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02186; alpha_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF239; TUBULIN ALPHA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}.
FT DOMAIN 38..235
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 237..382
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAJ87187.1"
FT NON_TER 401
FT /evidence="ECO:0000313|EMBL:CAJ87187.1"
SQ SEQUENCE 401 AA; 44433 MW; 9537953ACC01002E CRC64;
NSPLVGNACW ELYCLEHGIQ FDGQMPADKT IGGGDDSFNT FFSETGAGKH VPRTIYLDLE
PTVIDEVRTG TYRQLYHPEQ LISGKEDAAN NYARGHYTVG KEIVDLALDR LRKLADQCTG
LQGFMVFNTV GGGTGSGLGS LLLERLSVDY GKKSKLGFCV YPSPQISTAV VEPYNAVLAT
HSLLEHTDVA VMLDNEAIYD ICRRCLDIER PTYTNLNRLI SQVISSLTAS LRFDGALNVD
ITEFQTNLVP YPRIHFMVSS YSPVISAEKA YHESLSVAEI TNSCFEPANM MTKCDPRHGK
YMACCMMYRG DVVPKDVNAA IATIKTKRTI QFVDWCPTGF KCGINYQPPT VVPGGDLAKV
QRACCMISNT TTVAEVFARI DHKFDLMYSK RAFVHWYVGE G
//
