ID A0LH86_SYNFM Unreviewed; 1628 AA.
AC A0LH86;
DT 12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT 12-DEC-2006, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Alpha-2-macroglobulin domain protein {ECO:0000313|EMBL:ABK16788.1};
DE Flags: Precursor;
GN OrderedLocusNames=Sfum_1095 {ECO:0000313|EMBL:ABK16788.1};
OS Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC Bacteria; Thermodesulfobacteriota; Syntrophobacteria; Syntrophobacterales;
OC Syntrophobacteraceae; Syntrophobacter.
OX NCBI_TaxID=335543 {ECO:0000313|EMBL:ABK16788.1, ECO:0000313|Proteomes:UP000001784};
RN [1] {ECO:0000313|EMBL:ABK16788.1, ECO:0000313|Proteomes:UP000001784}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 10017 / MPOB {ECO:0000313|Proteomes:UP000001784};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CP000478; ABK16788.1; -; Genomic_DNA.
DR RefSeq; WP_011697959.1; NC_008554.1.
DR STRING; 335543.Sfum_1095; -.
DR KEGG; sfu:Sfum_1095; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_002018_1_0_7; -.
DR InParanoid; A0LH86; -.
DR OrthoDB; 9767116at2; -.
DR Proteomes; UP000001784; Chromosome.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF01835; MG2; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001784};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1628
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002626218"
FT DOMAIN 696..842
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 903..993
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1628 AA; 178711 MW; E9CFD269ECEB6B8B CRC64;
MKIERLVFLF AVLGLLLPVV AAPPAHAGSP FYLTVDRSFS HNEKPQLRID YTDPSKPMLL
RVLRPKDLDR FLDGQFNVSR SYERPVSQLN PGHYFVKGLN QAESPLKTWR GMLSAEFRKN
FKDTAFNKAL LDTTPGDLAA PPHQVVHGPP TGLGVVREYY VDLEHAGTDA KDIGWWFADS
GWQERSYKVR TIALDPLPDG VYLIQAVSGT AEGQCLMQVS SLAAQVKQST EQLVVRVIDR
EQQPVRGAAV SYRDGRGKWI DVGRKTDGAG EVFFSNPAGN LDGKLLVRAQ TGDGRQALTD
TDFLPAVSND DSVFIVTDRP IFKPGETFFY KGMVRALANG ELKTPDFAGK QARITLVRSD
GKDTGLQAAV PVTDFASFSG SFGLDEAQTP GLYRLIAELE GKPYGGEFRV RDYVKPVFYM
ELIERSPTVV PGEPFAVKFR TRRYSGGVPR DVKYEVYLYQ KKFEAPQWVA EAGGGLGTGT
DYFGQVRSAS ALTEPRRIYS SVEERLADAA REYGMNTWDS APLIDESGET SFSFTVPKTD
SAAQGEWIYT VMVRALDRAG SQAILTENIY MTVSEAQPSI RFSKTIAQVG EKGLTVSVRS
TYPDGKPAPN AGGVLDIGIE RGGDPAAGFV KLPFTTDARG NRDIELPELT GRGRLRAVAT
LETLDGKPMK HPAASQPVAM VVGGAQGEAV LDNRELELYT AGTILSPGEK AKVFALLPGD
WGRNGKGTVW ETISGRKIYG VNSRECQGRS WWFEVEARPE YGTGFYHTVT VPVSGGKYRE
QTLGFRIIPR AKRLTVDIRP EREEWEPLKP FRIDLEVKDA EGRPSPDTEL TVTIVDRAVY
AVQSELRPGV FDFFYPLPRL NLATFYSDEL QGYGYADLLK KPNFSLGALK SRSKLPKKAM
RDTAGWFPHV VTDGMGRASI TVDLPANVTE WLVTAIAADK TGRVGEATGR FRTVTDILRE
VIAPQFLRLG EEALVHLKTV NQADRTVSLK TRIELDGGVS LKQGRQEEEF TIEKQGERLS
PLVLEAAGGQ GTATLRVASE AREDIHVGGA EEFDIPLRPA STRLVFPGVA DKDRLIARLP
KAGKVGEVKV QVVSGLLGAA LNAAAVLVAY PYGCTEQLVH STVPNLVLMD LVRRAGLTRE
DLGPLADVLS RAESNAVFGI RKLIRNQKTD GGFGLWPADP EPSIGVTVTA LYALKFAGDL
KVEGAQGAYF KALDWLRNAR RAPEYRRQGG TVVGYELARL AELRFYDSQF EEQIAYVENL
LGDKTVPVPD LVNGLALFAG YRKNSWYRFN ERFKDSGAME ELIEKLKKAL EAFDPDVYLK
AAGEDWEAID SLGFGFGVPS IVSAAMGVME ELDALPQELE AKLTRILLAR MKNGYWTSTF
DTAQVIFNTR KILEKQARAV AEEAKTGRPA LVVRKADGQV LGELARIPAG FVGTFADPGT
PEQVSELRLE GLGPTDSAYS ATAVDVPYEA TAPGSTGLSV ERTFRRITPG GSEPLDLSRP
LRKGDTVVSE IRVRRNPVEE VTYIPSRFLV IEDSVPSLAR PVDDDRVALA DAGIRLENET
YWGLVMDTQR HPDRTVRIAK VLPRGEITIY QVWQAAFGGT AAVPPAVAFD MYDESVRGNT
GAGRIRVE
//
