ID   A0LHH5_SYNFM            Unreviewed;       631 AA.
AC   A0LHH5;
DT   12-DEC-2006, integrated into UniProtKB/TrEMBL.
DT   12-DEC-2006, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Adenylyl cyclase class-3/4/guanylyl cyclase {ECO:0000313|EMBL:ABK16877.1};
GN   OrderedLocusNames=Sfum_1184 {ECO:0000313|EMBL:ABK16877.1};
OS   Syntrophobacter fumaroxidans (strain DSM 10017 / MPOB).
OC   Bacteria; Thermodesulfobacteriota; Syntrophobacteria; Syntrophobacterales;
OC   Syntrophobacteraceae; Syntrophobacter.
OX   NCBI_TaxID=335543 {ECO:0000313|EMBL:ABK16877.1, ECO:0000313|Proteomes:UP000001784};
RN   [1] {ECO:0000313|EMBL:ABK16877.1, ECO:0000313|Proteomes:UP000001784}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 10017 / MPOB {ECO:0000313|Proteomes:UP000001784};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Pitluck S., Goltsman E.G.,
RA   Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R.,
RA   McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J.,
RA   Stams A.J.M., Worm P., Henstra A.M., Richardson P.;
RT   "Complete sequence of Syntrophobacter fumaroxidans MPOB.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP000478; ABK16877.1; -; Genomic_DNA.
DR   RefSeq; WP_011698048.1; NC_008554.1.
DR   AlphaFoldDB; A0LHH5; -.
DR   STRING; 335543.Sfum_1184; -.
DR   KEGG; sfu:Sfum_1184; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG5616; Bacteria.
DR   HOGENOM; CLU_019981_0_0_7; -.
DR   InParanoid; A0LHH5; -.
DR   Proteomes; UP000001784; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 3.40.50.10070; TolB, N-terminal domain; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR   PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR   Pfam; PF12895; ANAPC3; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50005; TPR; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001784};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          12..126
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
FT   REPEAT          466..499
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          500..533
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   631 AA;  69938 MW;  9B4984F6F9BED35C CRC64;
     MGTNGFKRKL AAILSADVAG YSRLMGEDEA ATVRTLEAYR RVISDLIQQH RGRVVDSPGD
     NILAEFVSVV DAVQCAVSAQ KEIQARNTEL PENRRMQFRI GINLGDVIEE GDRIYGDGVN
     IAARLESLAD PGGICVSKTA FEHIESKLPL GYEYLGEQTV KNIAKPICAY KVQMERRVTV
     KDHAEAKSKG GTWHRPLIVA LAGVLLITVV AAALWQFDFL PVRTRVDDTT VQRMAFPLPD
     KPSIAVMPFV NMTGEQSQDF FCDGLSESLI AALSRVPELF VIGRDSTFIY KGRAAPMRQV
     SEDLGVRYVL EGSVQRAGDR VRVTAQLIDA LKGHHLWSER YDRNVKDIFE LQDEISMKIL
     TELRVKITEG EAARILPKGT NNLQAYLKVL EGEWYRNQNN KEANNVAKRL YHEAVELDPA
     YAMAYVGLAR AQGFDVWLGA SKSPKETLAD AMKSARKAIE LDDSSAEANA AASAVLVAMR
     EHEKAIEVGE RAVTLNPNSA NALYTLGMVL NYAGRSEEAL PLLRQAVRFN PVVPKYYHHF
     STACRETGRY EEGIAALKTS LGRVPDDVLA NVVLATLYVY AGREDEARAA VAEVRRIDPG
     FSLERFARGS PWKEGPKRDR FIDALRRAGL K
//