ID A0PU18_MYCUA Unreviewed; 988 AA.
AC A0PU18;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Ribonuclease E Rne {ECO:0000313|EMBL:ABL05837.1};
GN Name=rne {ECO:0000313|EMBL:ABL05837.1};
GN OrderedLocusNames=MUL_3715 {ECO:0000313|EMBL:ABL05837.1};
OS Mycobacterium ulcerans (strain Agy99).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=362242 {ECO:0000313|EMBL:ABL05837.1, ECO:0000313|Proteomes:UP000000765};
RN [1] {ECO:0000313|EMBL:ABL05837.1, ECO:0000313|Proteomes:UP000000765}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Agy99 {ECO:0000313|EMBL:ABL05837.1,
RC ECO:0000313|Proteomes:UP000000765};
RX PubMed=17210928; DOI=10.1101/gr.5942807;
RA Stinear T.P., Seemann T., Pidot S., Frigui W., Reysset G., Garnier T.,
RA Meurice G., Simon D., Bouchier C., Ma L., Tichit M., Porter J.L., Ryan J.,
RA Johnson P.D., Davies J.K., Jenkin G.A., Small P.L., Jones L.M., Tekaia F.,
RA Laval F., Daffe M., Parkhill J., Cole S.T.;
RT "Reductive evolution and niche adaptation inferred from the genome of
RT Mycobacterium ulcerans, the causative agent of Buruli ulcer.";
RL Genome Res. 17:192-200(2007).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; CP000325; ABL05837.1; -; Genomic_DNA.
DR RefSeq; WP_011741442.1; NC_008611.1.
DR AlphaFoldDB; A0PU18; -.
DR KEGG; mul:MUL_3715; -.
DR eggNOG; COG1530; Bacteria.
DR HOGENOM; CLU_003468_2_0_11; -.
DR Proteomes; UP000000765; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004540; F:RNA nuclease activity; IEA:InterPro.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd04453; S1_RNase_E; 1.
DR Gene3D; 1.10.10.2480; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR019307; RNA-bd_AU-1/RNase_E/G.
DR InterPro; IPR004659; RNase_E/G.
DR InterPro; IPR003029; S1_domain.
DR NCBIfam; TIGR00757; RNaseEG; 1.
DR PANTHER; PTHR30001; RIBONUCLEASE; 1.
DR PANTHER; PTHR30001:SF0; RIBONUCLEASE G; 1.
DR Pfam; PF10150; RNase_E_G; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 384..461
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 133..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..988
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..160
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..231
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..323
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 862..950
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 988 AA; 106966 MW; 86E6AC7E1C23861D CRC64;
MVDGAPSSDP ENEPTQREDL PDRLRVHSLA RTLGTSSRRV LDALSALDGR IRSAHSSVDR
VDAVRVRDLL AEQPAEEGQA EEDQQAPDAV AAEVPDAPGE PAEPESRLML ETQETVQVVE
TWVERPHYMP LFVAPQPISE PVAGDDADDE SGDEGDDDEE QADRPGNRRR RRGRRGRGRG
RGEQGANDGQ DQPGDDGDEA PQKAGGNSTS SDDSEAQDGA DSEESDNGDD DNGSADGASR
RRRRRRRRKS GAGDDGDEGP APDDPPNTVV HERAPRSGDK SGNSDSGDDS GGNEIKGIDG
STRLEAKRQR RRDGRDAGRR RPPVLSEAEF LARREAVERV MVVRDRVRTE PPHPGSRYTQ
IAVLEDGIVV EHFVTSAASA SLVGNIYLGI VQNVLPSMEA AFVDIGRGRN GVLYAGEVNW
DAAGLGGADR KIEQALKPGD YIVVQVSKDP VGHKGARLTT QVSLAGRYLV YVAGASSTGI
SRKLPDTERQ RLKEILREVV PSDAGVIIRT ASEGVKEDDI RADVTRLQER WNQIEAKAVE
IKQKAAGAAV ALYEEPDVLV KVIRDLFNED FAGLVVSGDD AWDTINEYVS SVAPDLVSKL
SKYEPAVGSE GQVGPDVFAV HRIDEHLAKA MDRKVWLPSG GTLVIDRTEA MTVVDVNTGK
FTGSGGNLEQ TVTKNNLEAA EEIVRQLRLR DIGGIVVIDF IDMVLESNRD LVLRRLTEAL
ARDRTRHQVS EVTSLGLVQL TRKRLGTGLI EAFSTSCPHC SGRGILLHAD PVDSAPTTGR
KADSGGRRNR RSKKNRAEEP SEKEAVAKVP TYAPGEHPMF KAMAASSSSE AEHGDGEVEE
SGEELTAAVD DQTAVQVALD LGETEESEET DGTDETDDFD DDSDDSDDSD EDDDTDETND
TDVDADEDED TDDDSDEDED TEDDDELDDD LDDELDDDDS DSDDEDSESE LTEPAAGRPA
ALEVTTIAER PRRRRAAGRP AGPPIHLG
//
