ID A0Q7T5_FRATN Unreviewed; 1339 AA.
AC A0Q7T5;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 107.
DE SubName: Full=HrpA-like helicase {ECO:0000313|EMBL:ABK90300.1};
DE SubName: Full=RNA helicase HrpA {ECO:0000313|EMBL:AJI60374.1};
DE EC=3.6.4.13 {ECO:0000313|EMBL:AJI60374.1};
GN Name=hrpA {ECO:0000313|EMBL:ABK90300.1};
GN OrderedLocusNames=FTN_1432 {ECO:0000313|EMBL:ABK90300.1};
GN ORFNames=AW25_569 {ECO:0000313|EMBL:AJI60374.1};
OS Francisella tularensis subsp. novicida (strain U112).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Francisellaceae; Francisella.
OX NCBI_TaxID=401614 {ECO:0000313|EMBL:ABK90300.1, ECO:0000313|Proteomes:UP000000762};
RN [1] {ECO:0000313|EMBL:ABK90300.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=U112 {ECO:0000313|EMBL:ABK90300.1};
RA Brittnacher M., Rohmer L., Zhou Y., Abmayr S., D'Argenio D., Bovee D.,
RA Chang J., Chen J., Drees B., Ernst R., Fong C., Forsman M., Gallagher L.,
RA Gallis B., Gillett W., Goodlett D., Guina T., Guenthner D., Haugen E.,
RA Hayden H., Jacobs M., Kang A., Larson Freeman T., Levy R., Lim R.,
RA Manoil C., Olson M.V., Radey M., Shaffer S., Svensson K., Taylor G.,
RA Wasnick M., Kaul R., Miller S.I.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000000762}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=U112 {ECO:0000313|Proteomes:UP000000762};
RX PubMed=17550600; DOI=10.1186/gb-2007-8-6-r102;
RA Rohmer L., Fong C., Abmayr S., Wasnick M., Larson Freeman T.J., Radey M.,
RA Guina T., Svensson K., Hayden H.S., Jacobs M., Gallagher L.A., Manoil C.,
RA Ernst R.K., Drees B., Buckley D., Haugen E., Bovee D., Zhou Y., Chang J.,
RA Levy R., Lim R., Gillett W., Guenthener D., Kang A., Shaffer S.A.,
RA Taylor G., Chen J., Gallis B., D'Argenio D.A., Forsman M., Olson M.V.,
RA Goodlett D.R., Kaul R., Miller S.I., Brittnacher M.J.;
RT "Comparison of Francisella tularensis genomes reveals evolutionary events
RT associated with the emergence of human pathogenic strains.";
RL Genome Biol. 8:R102.1-R102.16(2007).
RN [3] {ECO:0000313|EMBL:AJI60374.1, ECO:0000313|Proteomes:UP000031872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=U112 {ECO:0000313|EMBL:AJI60374.1,
RC ECO:0000313|Proteomes:UP000031872};
RX PubMed=25931589;
RA Johnson S.L., Daligault H.E., Davenport K.W., Coyne S.R., Frey K.G.,
RA Koroleva G.I., Broomall S.M., Bishop-Lilly K.A., Bruce D.C., Chertkov O.,
RA Freitas T., Jaissle J., Ladner J.T., Rosenzweig C.N., Gibbons H.S.,
RA Palacios G.F., Redden C.L., Xu Y., Minogue T.D., Chain P.S.;
RT "Genome sequencing of 18 francisella strains to aid in assay development
RT and testing.";
RL Genome Announc. 3:0-0(2015).
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DR EMBL; CP000439; ABK90300.1; -; Genomic_DNA.
DR EMBL; CP009633; AJI60374.1; -; Genomic_DNA.
DR RefSeq; WP_003040385.1; NZ_CP009633.1.
DR KEGG; ftn:FTN_1432; -.
DR KEGG; ftx:AW25_569; -.
DR BioCyc; FTUL401614:G1G75-1480-MONOMER; -.
DR Proteomes; UP000000762; Chromosome.
DR Proteomes; UP000031872; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR024590; HrpA_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010222; RNA_helicase_HrpA.
DR NCBIfam; TIGR01967; DEAH_box_HrpA; 1.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF83; PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF11898; DUF3418; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000313|EMBL:ABK90300.1};
KW Hydrolase {ECO:0000313|EMBL:AJI60374.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 68..229
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 249..418
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 1248..1275
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1339 AA; 154575 MW; 62C7FCBFCFB49CA5 CRC64;
MSIHIDAFLN QIPTKFRGKF ISVIKNKNLP NQQLLEQLQV LAEQTKQKIL PKITYPDLPV
AERVDDIKKL LQDNQVIVVA GETGSGKSTQ LPKICLDLGL GKRGLIGHTQ PRRLAARSIA
SRIASEIGDQ SKVSFKIRFS DQTSENTLIK VMTDGVLLSE IKNDRFLSQY EVIIIDEAHE
RSLNIDFLLG CIKKILPFRP DLKVIITSAT IDHQKFINFF QNAKDIIISG RTYPVEIRYQ
NDEDFDEFSL QERILYALDE LGRGDVLVFL PTERDIHETL AYLNKQNLRF TEVLPLFSRL
SNKDQNKIFN PEGSVRRVIL ATNVAETSLT VPRIKYVIDS GLARISRYSY RTKVQRLPIE
KISQASANQR AGRCGRLSAG ICIRLYSEED FNNRKEYTEP EILRTNLASV ILQMLFLKLG
SIQDFPFIDA PDARFVKDGF KLLFELQAIS ELNYSKPKIT DDGMKMAVMP LDPKLAKIVI
EGYRQNTLRE IVSIVSFLSV QDPRERPLNL QQKADEKHSI DKDKSSDFVA ILNLANRLNS
DLKGLSNREK KEYFKKNFIS PVRFNEWNDI YRQIIEVIHG FGWKLNSQLV IKKDSSDSGL
DLESFEHRGQ SHDNEILKQV HNDRQILTNS SNIKINLHSH ESANLIANDQ NLKNTRLHAY
DSASAMINYE NLHKAIASGF LSNIGYNYEN AEYLGARGLK FFIFPGSSQF KAKPKWLLSS
EIVETTKTYA RNVAKIEPEW LESLASHLVK KHYDEPVWSK KRRAVIVNER VTLYGLEIVS
KRVVQYSKIN PREAREIFIR EALVNGDFDS KAYFYQQNLK LINQVEDLEN KSRRKDILVD
EQTMFEHYDA FIPNEVCDGA TFDKWLKSIT KEQQKGFIFD MEILMQHDAK EITQQKFPDV
LTIGDMHLPL EYNFDPLDER DGATVTIPIV FINNISSAVL EWGVYGFLYD KIVALLRALP
KNIRKNCVPV PTYAQAIFES LDFDKDRYTP LKSVIAKHIT RIVGFVVDET VWQNEELDKY
LVLNIKVVDE HGKTLALGKD INTLKEKLKN LVNKPKQEVD EKIYYDWDFA DIALTNQIKE
YGIVLKVYNC LEEYKGGVKL SYKSTLAEAQ SCMKRALKRL IKIRLQNQLS QKIKNNDLTS
LSMSLKLSDS KDSVIDKVID LSFFDNIELP YTKGDFERFY ALGMQKFVSN KSKVEALLLE
MTKFKTQLEK KLNAKKIPLN FIELFTAVRN ELNELFTDNY LSQPMIYLQR YKYYIQALEN
RLDKAKLNLQ RDRIYQLEVD ELKAKLAKKL VAKHLSTGDE EVTKIRFLIK ELWISWYLQN
VKTSESVSVK KILVYINQI
//
