ID A0SJF6_PLAFA Unreviewed; 376 AA.
AC A0SJF6;
DT 09-JAN-2007, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2007, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
DE Flags: Fragment;
GN Name=MSP-1 {ECO:0000313|EMBL:ABF18722.1};
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:ABF18722.1};
RN [1] {ECO:0000313|EMBL:ABF18722.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KCH-10 {ECO:0000313|EMBL:ABF18722.1};
RX PubMed=18053992; DOI=10.1016/j.exppara.2007.10.001;
RA Mehrizi A.A., Zakeri S., Salmanian A.H., Sanati M.H., Djadid N.D.;
RT "Plasmodium falciparum: sequence analysis of the gene encoding the C-
RT terminus region of the merozoite surface protein-1, a potential malaria
RT vaccine antigen, in Iranian clinical isolates.";
RL Exp. Parasitol. 118:378-385(2008).
CC -!- FUNCTION: By binding to host proinflammatory cytokine S100P may
CC interfere with host immune responses. {ECO:0000256|ARBA:ARBA00043850}.
CC -!- SUBUNIT: Interacts with host SLC4A1/Band 3 (via 5ABC region) on the
CC host erythrocyte surface in a sialic acid-independent manner.
CC {ECO:0000256|ARBA:ARBA00044022}.
CC -!- SUBUNIT: Interacts with host glycophorin GYPA in a sialic acid-
CC independent manner. {ECO:0000256|ARBA:ARBA00044006}.
CC -!- SUBUNIT: Interacts with host proinflammatory cytokine S100P; the
CC interaction blocks S100P inflammatory and chemotactic activities.
CC {ECO:0000256|ARBA:ARBA00044008}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00043950}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00043950}.
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DR EMBL; DQ489594; ABF18722.1; -; Genomic_DNA.
DR AlphaFoldDB; A0SJF6; -.
DR SMR; A0SJF6; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Merozoite {ECO:0000313|EMBL:ABF18722.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT TRANSMEM 357..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..190
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 268..304
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ABF18722.1"
SQ SEQUENCE 376 AA; 43218 MW; EB2A72EDF231A5AF CRC64;
AVTPSVIDNI LSKIENEYEV LYLKPLAGVY RSLKKQLENN VMTFNVNVKD ILNSRFNKRE
NFKNVLESDL IPYKDLTSSN YVVKDPYKFL NKEKRDKFLS SYNYIKDSID TDINFANDVL
GYYKILSEKY KSDLDSIKKY INDKQGENEK YLPFLNNIET LYKTVNDKID LFVIHLEAKV
LNYTYEKSNV EVKIKELNYL KTIQDKLADF KKNNNFVGIA DLSTDYNHNN LLTKFLSTGM
VFENLAKTVL SNLLDGNLQG MLNISQHQCV KKQCPQNSGC FRHLDEREEC KCLLNYKQEG
DKCVENPNPT CNENNGGCDA DAKCTEEDSG SNGKKITCEC TKPDSYPLFD GIFCSSSNFL
GISFLLILML ILYSFI
//
